血清环状RNA ACAP2、环状RNA CDR1as水平与ST段抬高型心肌梗死患者病情严重程度及预后的关系OA
Serum levels of circular RNA ACAP2 and circular RNA CDR1as in relation to disease severity and prognosis of patients with ST-segment elevation myocardial infarction
目的 探讨血清环状RNA(circRNA)ACAP2、circRNA CDR1as 水平与ST段抬高型心肌梗死(STEMI)患者病情严重程度及预后的关系.方法 选取 2021 年 1 月至 2023 年 11 月河北工程大学附属医院收治的 190 例 STEMI 患者为研究对象,根据 Gensini 评分将患者分为轻度组 98 例及重度组 92 例;根据不同预后情况将患者分为预后良好组138 例和预后不良组 52 例,采用 qRT-PCR 检测 circRNA ACAP2、circRNA CDR1as 水平;采用 Pearson 法分析血清 circRNA ACAP2 水平与 circRNA CDR1as 水平的相关性;采用Spearman法分析circRNA ACAP2、circRNA CDR1as 水平与 Gensini 评分的相关性;STEMI 患者预后的影响因素采用 Logistic 回归分析;ROC曲线分析血清circRNA ACAP2、circRNA CDR1as 水平对STEMI患者预后的预测价值.结果 重度组血清 circRNA ACAP2、circRNA CDR1as 水平均高于轻度组(t=17.535、27.748,P<0.05).Pearson相关性分析显示血清circRNA ACAP2 与circRNA CDR1as 呈正相关(P<0.05),Spearman相关性分析显示血清 circRNA ACAP2、circRNA CDR1as 均与 Gensini 评分呈正相关(P<0.05).预后良好组和预后不良组发病时间、Killip 分级、支架置入数、血清 circRNA ACAP2、circRNA CDR1as水平比较差异有统计学意义(t/χ2=10.153、7.154、15.882、29.436、33.294,P<0.05).多因素Logistic回归分析结果显示,发病时间、Killip分级、支架置入数、circRNA ACAP2、circRNA CDR1as 是 STEMI 患者预后的影响因素(P<0.05).ROC 曲线结果显示,血清 circRNA ACAP2、circRNA CDR1as 预测 STEMI 患者预后的 AUC 为 0.843、0.818,两者联合预测 STEMI 患者预后的 AUC 为 0.900,两者联合优于各自单独预测(Z=2.563、2.601,P<0.05).结论 STEMI患者血清 circRNA ACAP2、circRNA CDR1as 水平与病情严重程度及预后关系密切,联合检测对预测患者预后有一定的临床价值.
Objective To investigate the relationship between serum circular RNA(circRNA)ACAP2 and circRNA CDR1as levels and the severity and prognosis of patients with ST-segment elevation myocardial infarction(STEMI).Methods A total of 190 STEMI patients admitted to the Affiliated Hospital of Hebei University of Engineering from January 2021 to November 2023 were enrolled as the study subjects.They were divided into a mild group with 98 cases and a severe group with 92 cases based on Gensini scores.According to different prognostic outcomes,patients were classified into a good prognosis group with 138 cases and a poor prognosis group with 52 cases.The levels of circRNA ACAP2 and circRNA CDR1as were detected using qRT-PCR.Pearson correlation analysis was used to examine the correlation between serum levels of circRNA ACAP2 and circRNA CDR1as.Spearman correlation analysis was applied to analyze the correlation between circRNA ACAP2 and circRNA CDR1as levels and Gensini scores.Logistic regression analysis was conducted to identify influencing factors for the prognosis in STEMI patients.ROC curve analysis was performed to evaluate the predictive value of serum circRNA ACAP2 and circRNA CDR1as levels for the prognosis of STEMI patients.Results The serum levels of circRNA ACAP2 and circRNA CDR1as in the severe group were significantly higher than those in the mild group(t=17.535,27.748,respectively;P<0.05).Pearson correlation analysis showed a positive correlation between serum levels of circRNA ACAP2 and circRNA CDR1as(P<0.05),and Spearman correlation analysis indicated that both serum circRNA ACAP2 and circRNA CDR1as levels were positively correlated with Gensini scores(P<0.05).The differences in onset time,Killip classification,number of stents implanted,and serum levels of circRNA ACAP2 and circRNA CDR1as between the good and poor prognosis groups were statistically significant(t/χ2=10.153,7.154,15.882,29.436,33.294,respectively;P<0.05).Multivariate Logistic regression analysis results indicated that onset time,Killip classification,number of stents implanted,circRNA ACAP2,and circRNA CDR1as were influencing factors for the prognosis of STEMI patients(P<0.05).ROC curve analysis showed that the AUCs for predicting the prognosis of STEMI patients using serum circRNA ACAP2 and circRNA CDR1as levels were 0.843 and 0.818,respectively.The combined prediction of the two indicators yielded an AUC of 0.900,which was better than the prediction of either marker alone(Z=2.563,2.601;P<0.05).Conclusion The serum levels of circRNA ACAP2 and circRNA CDR1as in STEMI patients are closely related to the severity and prognosis of the disease.Their combined detection has certain clinical value for predicting patient prognosis.
李彦芳;石雪;宋利华;赵丹华;袁江永
056002 邯郸,河北工程大学附属医院心血管内科056002 邯郸,河北工程大学附属医院心血管内科056002 邯郸,河北工程大学附属医院心血管内科056002 邯郸,河北工程大学附属医院心血管内科056002 邯郸,河北工程大学附属医院心血管内科
环状RNA ACAP2环状RNA CDR1asST段抬高型心肌梗死预后
Circular RNA ACAP2Circular RNA CDR1asST-segment elevation myocardial infarctionPrognosis
《心脑血管病防治》 2026 (4)
17-21,45,6
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