血清TRPV4联合CysC、Lp-PLA2对原发性高血压患者左心室肥厚的诊断价值OA
Diagnostic value of serum TRPV4 combined with CysC and Lp-PLA2 for left ventricular hypertrophy in patients with primary hypertension
目的 探讨血清瞬时受体电位阳离子通道亚家族 V 成员 4(TRPV4)联合胱抑素 C(CysC)、脂蛋白相关磷脂酶A2(Lp-PLA2)对原发性高血压患者左心室肥厚(LVH)的诊断价值.方法 选取2022年1月至2024年10月在北京市普仁医院心血管内科就诊的126例原发性高血压患者作为研究对象,进行超声心动图检查并计算左心室质量指数(LVMI),根据 LVMI 将患者分为LVH 组 54 例和非 LVH 组 72 例.比较两组患者一般资料及血清 TRPV4、CysC、Lp-PLA2 水平,采用多因素 Logistic 回归分析原发性高血压患者 LVH 的影响因素,采用 Pearson 分析原发性高血压患者血清 TRPV4、CysC、Lp-PLA2 水平与 LVMI 的相关性,采用 ROC 曲线分析血清 TRPV4、CysC、Lp-PLA2 对患者 LVH 的诊断价值.结果 LVH 组的年龄、高血压病程及血清 TRPV4、CysC、Lp-PLA2 水平高于非 LVH 组,差异有统计学意义(t=2.641、2.220、7.168、6.894、6.015,P<0.05);多因素 Logistic 回归分析显示,血清 TRPV4、CysC、Lp-PLA2 水平升高是原发性高血压患者 LVH 的危险因素(P<0.05);血清 TRPV4、CysC、Lp-PLA2 水平与 LVMI 呈正相关(r=0.414、0.339、0.372,P<0.05);血清 TRPV4、CysC、Lp-PLA2 联合诊断 LVH 的 AUC 高于单独诊断(Z=5.812、6.256、6.091,P<0.05).结论 血清 TRPV4、CysC、Lp-PLA2 水平升高与原发性高血压患者LVH相关,联合检测对LVH具有诊断价值.
Objective To investigate the diagnostic value of serum transient receptor potential cation channel subfamily V member 4(TRPV4)combined with cystatin C(CysC)and lipoprotein-associated phospholipase A2(Lp-PLA2)for left ventricular hypertrophy(LVH)in patients with primary hypertension.Methods A total of 126 patients with primary hypertension who were admitted to the Department of Cardiovascular Medicine at Puren Hospital in Beijing from January 2022 to October 2024 were selected as the study subjects.Echocardiography was performed,and the left ventricular mass index(LVMI)was calculated.Based on LVMI,patients were divided into the LVH group(54 cases)and the non-LVH group(72 cases).General data and serum levels of TRPV4,CysC,and Lp-PLA2 were compared between the two groups.Multivariate Logistic regression analysis was used to identify influencing factors for LVH in primary hypertension patients.Pearson correlation analysis was employed to assess the relationships between the serum levels of TRPV4,CysC,Lp-PLA2 and LVMI in primary hypertension patients.Receiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic value of serum TRPV4,CysC,and Lp-PLA2 for LVH in these patients.Results Compared to the non-LVH group,the LVH group exhibited significantly higher age,duration of hypertension,and serum levels of TRPV4,CysC,and Lp-PLA2(t=2.641,2.220,7.168,6.894,6.015,respectively;P<0.05).Multivariate Logistic regression analysis revealed that elevated serum levels of TRPV4,CysC,and Lp-PLA2 were risk factors for LVH in patients with primary hypertension(P<0.05).Serum TRPV4,CysC,and Lp-PLA2 levels showed positive correlations with LVMI(r=0.414,0.339,0.372;P<0.05).The area under the curve(AUC)of the combined diagnosis of LVH by serum TRPV4,CysC,and Lp-PLA2 was significantly higher than that of any individual marker(Z=5.812,6.256,6.091,respectively;P<0.05).Conclusion Elevated serum levels of TRPV4,CysC,and Lp-PLA2 are associated with LVH in patients with primary hypertension,and their combined detection has diagnostic value for LVH.
周丽梅;王婷婷;支晓萌
100062 北京,北京市普仁医院心血管内科100062 北京,北京市普仁医院心血管内科100062 北京,北京市普仁医院心血管内科
原发性高血压左心室肥厚瞬时受体电位阳离子通道亚家族V成员4胱抑素C脂蛋白相关磷脂酶A2
Primary hypertensionLeft ventricular hypertrophyTransient receptor potential cation channel subfamily V member 4Cystatin CLipoprotein-associated phospholipase A2
《心脑血管病防治》 2026 (4)
13-16,4
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