首页|期刊导航|妇儿健康导刊|30例不完全性川崎病的临床特征分析

30例不完全性川崎病的临床特征分析OA

Clinical characteristics analysis of 30 cases of incomplete Kawasaki disease

中文摘要英文摘要

目的 探讨不完全性川崎病(IKD)的临床特征,为基层医院早期识别IKD提供参考.方法 回顾性分析 2020 年1月至 2025 年 8 月在横州市人民医院儿科住院治疗的 30 例IKD患儿的临床资料,统计患儿发热特征、临床症状体征占比、实验室指标异常情况、心脏超声表现及治疗反应.结果 IKD患儿均表现为持续性发热(≥5 d),早期临床症状体征以颈淋巴结肿大(63.3%)、眼结膜充血(53.3%)、口唇皲裂/草莓舌(43.3%)、皮疹(40.0%)为主,手足硬肿(6.7%)发生率较低,指端/肛周脱皮(26.7%)出现时间晚,症状体征分布分散,易与呼吸道感染、急性颈淋巴结炎等疾病混淆.实验室指标以红细胞沉降率>20 mm/h(100.0%)、血小板计数≥579×109/L(83.3%)、C反应蛋白≥10 mg/L(93.3%)、血浆D-二聚体≥0.5 mg/L(76.7%)、中性粒细胞比值>57%(73.3%)、白细胞计数>14.6×109/L(50.0%)、血红蛋白<97 g/L(40.0%)为突出特征.冠脉扩张发生率达40.0%,所有患儿经静脉注射人免疫球蛋白(2 g/kg)联合阿司匹林治疗后体温均降至正常,绝大多数体温在1~2 d内恢复正常,预后良好.结论 IKD的临床特征以持续性发热、分散的非典型症状体征及多项炎症与凝血指标异常为主要表现,早期心脏超声检查有助于发现冠脉病变.

Objective To explore the clinical characteristics of incomplete Kawasaki disease(IKD)and provide reference for early identification of IKD in primary hospitals.Methods A retrospective analysis was conducted on the clinical data of 30 pediatric patients with IKD hospitalized in the Department of Pediatrics at Hengzhou People's Hospital from January 2020 to August 2025.The fever patterns,incidence of clinical symptoms and signs,laboratory abnormalities,echocardiographic findings,and treatment responses were recorded.Results All children with IKD presented with persistent fever(≥5 days).Early clinical symptoms and signs were primarily characterized by cervical lymphadenopathy(63.3%),conjunctival congestion(53.3%),and chapped lips/strawberry tongue(43.3%),and rash(40.0%).The incidence of hand and foot swelling(6.7%)was relatively low,and peeling of the fingertips and perianal area(26.7%)appeared later in the course of the disease.The distribution of symptoms and signs was scattered,making the condition easily confused with respiratory infections,acute cervical lymphadenitis,and other diseases.Laboratory findings primarily included erythrocyte sedimentation rate>20 mm/h(100.0%),platelet count≥579×109/L(83.3%),C-reactive protein≥10 mg/L(93.3%),plasma D-dimer≥0.5 mg/L(76.7%),neutrophil percentage>57%(73.3%),white blood cell count>14.6×109/L(50.0%),and hemoglobin<97 g/L(40.0%).The incidence of coronary dilation reached 40.0%.After treatment with intravenous human immunoglobulin(2 g/kg)combined with Aspirin,all pediatric patients achieved normal body temperature,with most recovering within 1-2 days,indicating favorable prognosis.Conclusion The clinical features of IKD are persistent fever,scattered atypical symptoms and signs,and abnormal inflammation and coagulation indexes.Early cardiac ultrasound examination is helpful to find coronary artery lesions.

黄小美;陆永杨

广西壮族自治区横州市人民医院儿科,广西横州 530300广西壮族自治区横州市人民医院儿科,广西横州 530300

医药卫生

不完全性川崎病临床症状体征实验室指标

Incomplete Kawasaki diseaseClinical symptom and signLaboratory indicator

《妇儿健康导刊》 2026 (8)

46-49,68,5

10.3969/j.issn.2097-115X.2026.08.010

评论