早产儿有血流动力学意义的动脉导管未闭的影响因素分析OA

Objective To analyze the influencing factors of hemodynamically significant patent ductus arteriosus(hsPDA)in premature infants.Methods A total of 150 premature infants with patent ductus arteriosus admitted to Department of Neonatology,Shenzhen Maternity&Child Healthcare Hospital,Southern Medical University from January to December 2024 were selected.According to the results of cardiac ultrasound hemodynamic standards,they were divided into hsPDA group(n=98)and non-hsPDA group(n=52).The single factor and logistic regression were used to analyze the influencing factors of hsPDA.Results The single-factor analysis showed that gestational age,birth weight,sepsis,respiratory distress syndrome(RDS),platelet count(PLT),platelet distribution width(PCT),large platelet ratio(P-LCR),mean platelet volume(MPV),and platelet distribution width(PDW)were associated with hsPDA(P<0.05).The multivariate logistic regression analysis revealed that RDS,low PLT,low PCT,low P-LCR,high MPV,and high PDW were independent risk factors for hsPDA,while birth weight was a protective factor(P<0.05).Conclusion The occurrence of hsPDA in premature infants is closely related to low platelet function and RDS.Monitoring of early platelet parameters can assist in clinical intervention.