肺部感染脓毒症主要证型与临床证据的相关性研究OA

Objective To explore the distribution patterns of traditional Chinese medicine(TCM)syndrome types in patients with pul-monary infection-related sepsis and their correlation with clinical evidence,providing a basis for the objectification of TCM syndrome dif-ferentiation.Methods Based on a multicenter study involving 31 hospitals nationwide,a total of 1150 patients with pulmonary infection-related sepsis were included.Their general information,TCM syndrome types(toxin-heat syndrome,blood-stasis syndrome,fu-qi blockage syndrome,acute deficiency syndrome),and relevant clinical indicators such as inflammation,coagulation,and organ function were collected for statistical analysis.Results The distribution of syndrome types was predominantly Blood-Stasis Syndrome(28.26%)and toxin-heat syndrome(26.96%),followed by acute deficiency syndrome(25.04%)and fu-qi blockage syndrome(19.74%).Patients with acute deficiency syndrome had the highest 28-day mortality rate(52.43%).Each syndrome type showed characteristic dif-ferences in inflammatory markers,coagulation function,disease severity scores,oxygenation index,lactate levels,etc.(P<0.05).Logistic regression analysis further revealed independent influencing factors for each syndrome type,such as a positive correlation between acute deficiency syndrome and SOFA score,a positive correlation between toxin-heat syndrome and body temperature,and a positive correlation between blood-stasis syndrome and D-dimer levels.Conclusion Different TCM syndrome types of pulmonary infection-related sepsis are closely associated with specific clinical-pathological features,exhibiting distinct modern medical indicator profiles.TCM syndrome differentiation can provide important references for assessing disease severity,predicting prognosis,and guid-ing individualized treatment.