首页|期刊导航|实用中医内科杂志|基于"虚痰瘀毒"理论的溃疡性结肠炎"炎癌转化"中医药防治探讨

基于"虚痰瘀毒"理论的溃疡性结肠炎"炎癌转化"中医药防治探讨OA

Discussion on the Prevention and Treatment of"inflammation-Cancer Transformation"in Ulcerative Colitis Based on the Theory of"Deficiency,Phlegm,Stasis and Toxicity"in Chinese Medicine

中文摘要英文摘要

溃疡性结肠炎(ulcerative colitis,UC)"炎癌转化"是UC从炎性反应-不典型增生-癌变的过程,在病机演变过程中,脾虚为疾病发生之基础,痰瘀为疾病进展之驱动因素,毒邪致变则为疾病恶化之关键,"虚痰瘀毒"理论贯穿于UC"炎癌转化"的发生发展及证候演变全过程.该文通过梳理相关文献,基于"虚痰瘀毒"理论探讨UC"炎癌转化"的现代生物学基础并梳理UC"炎癌转化"中药防治机制,提出防治UC"炎癌转化"应分阶段精准辨治,且补虚、化痰、祛瘀、解毒之法应贯穿防治全程;中医药主要通过降低促炎性因子水平、降低血液黏稠度,清除内毒素等以活血化痰解毒,调整免疫等以扶正达到防治UC"炎癌转化"的目的.以期为中医药干预与阻断UC"炎癌转化"提供理论参考.

The"inflammation-cancer transformation"of ulcerative colitis(UC)is the process of UC from inflammation-atypical hyperplasia-carcinoma,in the process of disease transformation,spleen deficiency is the basis of disease develop-ment,phlegm and stasis are the driving factors of disease development,and toxicity is the key to disease deterioration."The"deficiency,phlegm,stagnation and toxicity"play an important role in the development and evolution of the symptoms of UC.By reviewing relevant literature,the author explored the modern biological basis of UC"inflammation and cancer transformation"based on the theory of"deficiency,phlegm,stasis and toxicity"and sorted out the prevention and treatment mechanism of UC"inflammation and cancer transformation"by Chinese medicine.We propose that the prevention and treatment of UC"inflamma-tion and transformation"should be done precisely in stages,and the treatment of deficiency,phlegm,stasis,and detoxification should be carried out throughout the prevention and treatment;Chinese medicine mainly reduces the level of pro-inflammatory factors,lowers blood viscosity,removes endotoxins,etc.to invigorate the blood,dissolve phlegm and detoxify the toxins,and adjusts immunity to achieve the prevention and treatment of UC"inflammation and transformation".The purpose of"inflamma-tion and cancer transformation".It is hoped that this paper can provide some theoretical basis for Chinese medicine to intervene and block the development of UC"inflammation and cancer transformation".

马澳伦;宁玲;李青;黄贵华

广西中医药大学,广西南宁 530023昆明市中医医院,云南 昆明 650011昆明市中医医院,云南 昆明 650011广西中医药大学,广西南宁 530023

医药卫生

溃疡性结肠炎炎癌转化病机中医药防治

ulcerative colitisinflammatory cancer transformationpathogenesisChinese medicineprevention and treat-ment

《实用中医内科杂志》 2026 (5)

16-19,后插1,5

国家自然科学基金项目(82360959)国医大师黄瑾明学术思想与临床诊疗传承发展研究中心建设项目(桂中医大党[2022]24号)广西研究生教育创新计划项目(YCBXJ2025008)

10.13729/j.issn.1671-7813.Z20230333

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