特发性肺纤维化与胃食管反流病相互影响的中西医研究进展OA

Idiopathic pulmonary fibrosis(IPF)is a chronic progressive interstitial pneumonia with unknown etiology.The prognosis of patients is poor and the mortality is high.At present,the research on its pathological mechanism is still unclear.At present,only pirfenidone and Nidanib are used to treat IPF,but the treatment effect is slightly poor,which can not completely cure patients.The prevalence of gastroesophageal reflux disease(GERD)is high in IPF patients.It is found that micro-breathing re-lated to GERD leads to persistent inflammation of lung structure,which accelerates the progress of IPF and can promote or induce pulmonary fibrosis.The respiratory mechanics changes caused by poor lung elasticity may also increase reflux,and the two may in-teract with each other.Traditional Chinese medicine believes that IPF and GERD are mostly caused by lung spleen deficiency,lung failure to declare and relieve depression,and spleen failure to transport,and the two affect each other,and then phlegm,blood stasis and toxin are combined in the lung.This paper discusses the long-term interaction between GERD and IPF,so as to pro-vide new ideas and views for the treatment of IPF.