PON1-Q192R基因多态性与冠心病患者冠状动脉病变严重程度的相关性OA

Objective To evaluate the association between the PON1-Q192R gene polymorphism and the severity of atherosclerotic lesions in coronary arteries among patients with coronary heart disease,and to analyze the influencing factors of the degree of coronary artery stenosis.Methods Patients diagnosed with coronary heart dis-ease at Northern Jiangsu People's Hospital between January 2024 and December 2024 were enrolled in this study.The PON1-Q192R genotype was detected using PCR-based pyrosequencing.Compare the baseline data of patients with distinct genotypes.Patients were categorized into groups based on the severity of coronary atherosclerosis ac-cording to the Gensini score system:mild stenosis group(＜20 points),moderate stenosis group(20-39 points),and severe stenosis group(≥40 points).The study examined the correlation between the PON1-Q192R gene poly-morphism and Gensini scores,and compared the distribution characteristics of different genotypes across coronary artery stenosis groups in patients with coronary heart disease.Univariate and multivariate logistic regression analy-ses were employed to investigate the associated factors influencing the degree of coronary artery stenosis.Results The median Gensini score showed that patients with the AG and AA genotypes were significantly higher than those with the GG genotype(P＜0.05).The proportion of patients with severe stenosis in the AG and AA genotypes was significantly higher than that in the GG genotype(P＜0.05).Comparing the distribution of the PON1-Q192R G/A alleles across different degrees of coronary artery stenosis also showed statistically significant differences(P＜0.05).Multivariate logistic regression analysis revealed that the AG genotype(OR=1.973,95％CI:1.078-3.610,P=0.027),AA genotype(OR=3.127,95％CI:1.245-7.853,P=0.015),hypertension(OR=2.234,95％CI:1.233-4.046,P=0.008),diabetes mellitus(OR=2.043,95％CI:1.064-3.920,P=0.032),and elevated LDL-C(OR=1.608,95％CI:1.157-2.234,P=0.005)were identified as risk factors for increased coronary artery steno-sis severity.Conclusions The PON1-Q192R gene polymorphism is significantly associated with an increased risk of coronary artery stenosis severity in patients with coronary heart disease.The PON 1-Q192R gene polymorphism can serve as an important indicator for predicting the severity of coronary artery stenosis in patients with coronary heart disease.