当归治疗2型糖尿病心肌病的潜在作用机制及研究进展OA

With the aging of society,the prevalence of diabetes-a common age-related metabolic disorder-has been steadily increasing.As a consequence,the incidence of diabetic cardiomyopathy(DCM),one of its major complications,has also risen significantly.DCM represents the most prevalent cardiovascular complication in patients with type 2 diabetes mel-litus(T2DM),characterized by structural and functional myocardial abnormalities independent of coronary artery disease or hypertension.This condition not only serves as a critical factor in cardiac impairment and heart failure among diabetic pa-tients but also constitutes a specific myocardial injury distinct from secondary damage caused by coronary artery disease.The pathogenesis of DCM typically involves inflammatory aging,oxidative stress,mitochondrial dysfunction,and metabolic dis-turbances.The traditional Chinese herb Angelica sinensis(Danggui)has demonstrated potential therapeutic value for DCM due to its diverse pharmacologically active components.This review elucidates the pathological mechanisms of DCM,the pri-mary active constituents of Angelica sinensis,and their mechanisms in ameliorating DCM,thereby providing novel insights into the relationship between diabetic cardiomyopathy and Angelica sinensis treatment.