基于TLR4/NF-κB信号通路中医药改善溃疡性结肠炎基础研究进展OA
Progress in basic research on TCM improvement of ulcerative colitis based on TLR4/NF-κ B signaling pathway
溃疡性结肠炎(ulcerative colitis,UC)是一种慢性炎症性肠道疾病,其发病机制涉及多种信号通路,其中 TOLL 样受体 4(Toll-like Receptor4,TLR4)/核因子-κB(Nuclear Factor-κB,NF-κB)信号通路在 UC 的发病过程中起着重要作用.近年来,中医药在 UC 治疗方面取得了显著进展,研究发现,中药单体及其提取物,中药复方,针灸、艾灸、穴位贴敷等外治法能够通过调节 TLR4/NF-κB 信号通路,使促炎因子与抗炎因子达到平衡状态,平衡肠道菌群,保护肠道黏膜屏障,改善 UC 的症状和病理生理过程,有望为 UC 的治疗提供新的思路和方法.
Ulcerative colitis(ulcerative colitis,UC)is a chronic inflammatory intestinal disease,whose pathogenesis involves various signaling pathways,among which the Toll-like receptor 4(Toll-like Receptor4,TLR4)/nuclear factor-κB(Nuclear Factor-κB,NF-κB)signaling pathway plays an important role in the pathogenesis of UC.In recent years,tradition-al Chinese medicine has made significant progress in UC treatment,research found that from the Chinese medicine monomer and extracts,traditional Chinese medicine compound,acupuncture,acupuncture and moxibustion,acupoint application com-prehensive analysis of traditional Chinese medicine can regulate TLR4/NF-κB signal pathway,make promote inflammatory factors and anti-inflammatory factors,balance the intestinal flora,protect the intestinal mucosal barrier,improve UC symp-toms and pathophysiological process,is expected to provide new ideas and methods for the treatment of UC.
闫婷;史英;张益珊;张璇;刘新阳;刘旭雯;蒙晓娟
陕西中医药大学,陕西 咸阳 712046陕西中医药大学第二附属医院,陕西 咸阳 712000陕西中医药大学第二附属医院,陕西 咸阳 712000陕西中医药大学第二附属医院,陕西 咸阳 712000陕西中医药大学,陕西 咸阳 712046陕西中医药大学,陕西 咸阳 712046陕西中医药大学第二附属医院,陕西 咸阳 712000
医药卫生
溃疡性结肠炎Toll样受体4/核因子-κB信号通路中医药机制
ulcerative colitisToll-like receptor4/nuclear factor-κB signaling pathwaytraditional Chinese medicinemechanism
《现代中医药》 2026 (3)
17-22,6
国家自然科学基金青年项目(82104396)陕西省科技厅青年项目(S2024-JC-QN-2019)陕西省科技厅青年项目(2022JM-506)陕西省中医药科技创新提质扩能计划(TZKN-CXPT-03)
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