药学综合创新实验:分子印迹聚合物制备及其在体内药物分析样品前处理中的应用OA

Under new pharmaceutical science initiatives and innovation training,we address complex biological sample analysis.A comprehensive pharmaceutical experiment was designed for this purpose.It integrates pharmaceutical analysis,polymer chemistry,and analytical chemistry.Advanced molecular imprinting technology(MIT)serves as the key tool.Cholic acid,a significant endogenous metabolite,is selected as the template.Cholic acid molecularly imprinted polymers(CA-MIPs)are synthesized via precipitation polymerization.Their structure is characterized using scanning electron microscopy(SEM)and Fourier transform infrared spectroscopy(FT-IR).The imprinting site and formation mechanism is elucidated.Adsorption performance is evaluated by high perfor-mance liquid chromatography(HPLC)and liquid chromatography-mass spectrometry(LC-MS).Selectivity and enrichment efficiency in plasma are assessed.The experiment covers material design,synthesis,and characterization.It also includes application performance evaluation.This demonstrates high-level innovation and challenge.The practice enhances students'innovative thinking and practical skills.It fosters social and professional responsibility.The project cultivates high-quality applied pharmaceutical talents.This represents a beneficial practice in holistic education.