针灸治疗慢性湿疹:一项系统评价OA

Objective:To systemically evaluate the effectiveness and safety of acupuncture and moxibustion for chronic eczema,and to provide evidence for acupuncture and moxibustion in the treatment of chronic eczema. Methods:Randomized controlled trials(RCTs)were retrieved from PubMed,Cochrane Library,China Na-tional Knowledge Infrastructure(CNKI),VIP database,Wanfang database and China Biology Medicine disc(CBM),from the inception of the database to April 23,2025.The control group were sham acupunc-ture and moxibustion,no treatment,or conventional western medication.The intervention group were acupuncture and moxibustion therapy or acupuncture and moxibustion on the basis of the interventions as the control group.Meta-analysis was performed by using RevMan5.4.0 software according to Cochrane systematic evaluation method. Results:Ultimately,53 RCTs were included.The results of the meta-analysis showed that compared with sham acupuncture and moxibustion,no treatment,or conventional western medication,acupuncture and moxibustion treatment for eczema area and severity index(EASI)score(mean difference[MD]=-2.23,95％confidence interval[CI]-2.61 to-1.85;P＜0.00001),visual analogue scale(VAS)score(standard-ized mean difference[SMD]=-1.45,95％CI-2.04 to-0.87;P＜0.00001),dermatology life quality index(DLQI)score(MD=-2.36,95％CI-3.25 to-1.48;P＜0.00001),immunoglobulin E(IgE)(SMD=-1.26,95％CI-2.46 to-0.05;P=0.04),the overall response rate(odds ratio[OR]=4.58,95％CI 3.84 to 5.46;P＜0.00001)and the recurrence rate(OR=0.14,95％CI 0.09 to 0.21;P＜0.00001)were all better than those in the control group,and there were no severe adverse events reported. Conclusion:Acupuncture and moxibustion can reduce the lesion area and severity of the patients with chronic eczema,effectively alleviate pruritus,improve the quality of life and decrease serum IgE.This therapy owns high overall response rate with low recurrence rate,and without severe adverse events,which is associated with a favorable long-term prognosis.