颈部肌张力障碍治疗研究进展OA
Research advances in treatment of cervical dystonia
颈部肌张力障碍(cervical dystonia,CD)是最常见的成人发作性局灶性肌张力障碍,可显著损害患者的自理能力及生活质量.目前的主要治疗手段包括肉毒毒素治疗、药物治疗、手术治疗、物理治疗、心理治疗以及中医药特色疗法等.本文对CD现有治疗方式进行文献回顾,总结了不同干预措施的疗效、安全性及局限性.研究发现,现有治疗手段对于CD运动症状的干预效果较为确切,然而针对抑郁和焦虑等非运动症状的疗效评价与临床关注仍存在明显不足.未来应致力于探索整合药物、手术、康复及心理干预的多模态个体化治疗方案,以实现对患者治疗需求的精准匹配以及生活质量的全面提升.
Cervical dystonia(CD)is the most common type of adult-onset focal dystonia,which can significantly impair patients'self-care ability and quality of life.Current mainstream therapeutic approaches include botulinum toxin therapy,pharmacotherapy,surgical treatment,physical therapy,psychological therapy,and characteristic therapies of traditional Chinese medicine(TCM).This paper conducts a literature review on the existing therapeutic modalities for CD and summarizes the efficacy,safety and limitations of different interventional measures.It is found that the existing therapies exert definite effects in managing the motor symptoms of CD,whereas obvious deficiencies remain in the efficacy evaluation and clinical attention to non-motor symptoms such as depression and anxiety.Future research should focus on exploring multimodal individualized treatment regimens integrating pharmacotherapy,surgery,rehabilitation and psychological intervention,so as to achieve precise matching of patients'treatment needs and comprehensive improvement of their quality of life.
庄子豪;张嘉程;苏楷涵;吕清波;李华南;王金贵
天津中医药大学第一附属医院推拿科,天津 300381||中医国家临床医学研究中心,天津 300381||国家中医药管理局推拿手法生物效应三级实验室,天津 300381||天津市卫生健康委员会中医推拿研究所,天津 300193天津中医药大学第一附属医院推拿科,天津 300381||中医国家临床医学研究中心,天津 300381||国家中医药管理局推拿手法生物效应三级实验室,天津 300381||天津市卫生健康委员会中医推拿研究所,天津 300193天津中医药大学第一附属医院推拿科,天津 300381||中医国家临床医学研究中心,天津 300381||国家中医药管理局推拿手法生物效应三级实验室,天津 300381||天津市卫生健康委员会中医推拿研究所,天津 300193现代中医药海河实验室,天津 301617天津中医药大学第一附属医院推拿科,天津 300381||中医国家临床医学研究中心,天津 300381||国家中医药管理局推拿手法生物效应三级实验室,天津 300381||天津市卫生健康委员会中医推拿研究所,天津 300193天津中医药大学第一附属医院推拿科,天津 300381||中医国家临床医学研究中心,天津 300381||国家中医药管理局推拿手法生物效应三级实验室,天津 300381||天津市卫生健康委员会中医推拿研究所,天津 300193
颈部肌张力障碍肉毒毒素深部脑刺激物理疗法
Cervical dystoniaBotulinum toxinDeep brain stimulationPhysiotherapy
《神经病学与神经康复学杂志》 2026 (2)
157-167,11
天津市中医药重点领域科研项目(2024001)现代中医药海河实验室科技项目(24HHZYSS00015)天津市南开区卫健委重点项目(20240204015) Key Field Research Project of Traditional Chinese Medicine of Tianjin(2024001)Science and Technology Project of Haihe Laboratory of Modern Traditional Chinese Medicine(24HHZYSS00015)Key Project of Health Commission of Nankai District,Tianjin(20240204015)
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