电针联合西药对肠道肿瘤术后便秘患者肠道功能的影响OA

Objective To observe the effects of electroacupuncture(EA)on intestinal function and clinical symptoms in patients with constipation after intestinal tumor surgery based on the brain-gut axis.Method Ninety patients with constipation after intestinal tumor surgery were randomly assigned to an observation group(45 cases;1 case of elimination and 3 dropouts)and a control group(45 cases;1 case of elimination and 4 dropouts).The control group received conventional Western medicine treatment,and the observation group additionally received EA treatment.The two groups were compared in terms of therapeutic efficacy,intestinal function(bowel movement frequency,defecation time,stool consistency,and intestinal transit time),clinical symptoms(constipation symptom scores and abdominal pain and bloating intensities),brain-gut axis-associated indicators[the serum levels of substance P(SP),vasoactive intestinal peptide(VIP),5-hydroxytrptamine(5-HT),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)],and gut microbiota in fecal samples[Firmicutes and Bacteroidetes and their ratios(F/B),as well as the relative abundance of Bifidobacterium,Lactobacillus,Escherichia].Result After treatment,the observation group had higher bowel movement frequencies and stool consistency scores compared to the control group(P＜0.05),and shorter defecation time and intestinal transit time(P＜0.05);the constipation symptom and visual analog scale(VAS)scores were significantly lower in the observation group than in the control group(P＜0.05);the levels of serum SP,VIP,and 5-HT were significantly higher in the observation group than in the control group(P＜0.05);the observation group had markedly lower levels of serum IL-6 and TNF-α compared to the control group(P＜0.05);compared to the control group,the observation group exhibited notably higher Chao1 and Shannon indexes of gut microbiota in fecal samples(P＜0.05)and a significantly lower F/B(P＜0.05);compared to the control group,the observation group demonstrated significantly lower levels of Firmicutes and Escherichia(P＜0.05)and higher levels of Bacteroidetes,Bifidobacterium,and Lactobacillus(P＜0.05).The observation group achieved a total effective rate of 92.7%,significantly higher than 77.5%in the control group(P＜0.05).Conclusion The combined use of EA and conventional Western medicine treatment can promote the release of serum SP,VIP,and 5-HT,to accelerate intestinal transit,inhibit inflammatory factors serum IL-6 and TNF-α to reduce inflammatory reactions,and optimize the composition of gut microbiota in patients with constipation after intestinal tumor surgery,thereby recovering intestinal function through multiple targets.