针刺联合质子泵抑制剂治疗胃食管反流病的疗效观察及对血清胃动素、生长激素释放肽水平的影响OA
Clinical observation on the efficacy of acupuncture combined with proton pump inhibitors in the treatment of gastroesophageal reflux disease and its effects on serum motilin and growth hormone-releasing peptide levels
目的 观察针刺联合质子泵抑制剂治疗胃食管反流病(gastroesophageal reflux disease,GERD)的临床疗效及对血清胃动素(motilin,MTL)、生长激素释放肽水平的影响.方法 将 123例 GERD 患者随机分为对照组(61 例,脱落 1 例)和试验组(62 例,脱落 2 例).对照组口服奥美拉唑肠溶胶囊,试验组在对照组基础上采用针刺治疗.比较两组治疗前后中医证候积分、胃肠激素水平[MTL、P 物质(substance P,SP)、血管活性肠肽(vasoactive intestinal polypeptide,VIP)和生长激素释放肽]、食管动力学[食管上括约肌压力(upper esophageal sphincter pressure,UESP)和食管下括约肌压力(lower esophageal sphincter pressure,LESP)]和生活质量评分[胃食管反流病健康相关生活质量量表(gastroesophageal reflux disease-health-related quality of life,GERD-HRQL)评分]变化,并比较两组临床疗效.结果 试验组总有效率为 96.7%,高于对照组的 83.3%(P＜0.05).治疗后,两组中医证候积分均降低(P＜0.05),且试验组低于对照组(P＜0.05).治疗后,两组血清MTL、生长激素释放肽和SP 水平均升高(P＜0.05),且试验组高于对照组(P＜0.05);两组血清VIP水平均降低(P＜0.05),且试验组低于对照组(P＜0.05).治疗后,两组 UESP 和 LESP 均升高,且试验组高于对照组(P＜0.05).治疗后,两组GERD-HRQL 评分均降低,且试验组低于对照组(P＜0.05).结论 针刺联合 PPI 治疗GERD的疗效突出,可调节胃肠激素水平及食管动力学水平,减轻患者症状,提升生活质量.
Objective To observe the clinical efficacy of acupuncture combined with proton pump inhibitors(PPIs)in the treatment of gastroesophageal reflux disease(GERD)and its effects on serum motilin(MTL)and growth hormone-releasing peptide levels.Method A total of 123 patients with GERD were randomly divided into a control group(61 cases,1 dropout)and an experimental group(62 cases,2 dropouts).The control group received oral omeprazole enteric-coated capsules,while the experimental group received acupuncture therapy in addition to the same treatment as the control group.Changes before and after treatment in traditional Chinese medicine(TCM)syndrome scores,gastrointestinal hormone levels[MTL,substance P(SP),vasoactive intestinal peptide(VIP),and growth hormone-releasing peptide],esophageal motility parameters[upper esophageal sphincter pressure(UESP)and lower esophageal sphincter pressure(LESP)],and quality of life scores[Gastroesophageal Reflux Disease-Health-Related Quality of Life(GERD-HRQL)]were compared between the two groups.Overall clinical efficacy was also evaluated.Result The total effective rate in the experimental group was 96.7%,which was significantly higher than that in the control group(83.3%)(P＜0.05).After treatment,TCM syndrome scores decreased in both groups(P＜0.05),with lower scores in the experimental group than in the control group(P＜0.05).Serum levels of MTL,growth hormone-releasing peptide,and SP increased in both groups after treatment(P＜0.05),and were higher in the experimental group than in the control group(P＜0.05).Serum VIP levels decreased in both groups after treatment(P＜0.05),with a greater reduction in the experimental group(P＜0.05).After treatment,both UESP and LESP increased in both groups,and the increases were more pronounced in the experimental group(P＜0.05).GERD-HRQL scores decreased in both groups after treatment,with lower scores in the experimental group than in the control group(P＜0.05).Conclusion Acupuncture combined with proton pump inhibitors shows significant efficacy in the treatment of GERD.This combined therapy can regulate gastrointestinal hormone levels and esophageal motility,alleviate clinical symptoms,and improve patients'quality of life.
史晓花;郭启涛;刘亚莉;赵志幸;李路宝;贾慧英;杨玉巧
邯郸市中医院,邯郸 056001邯郸市中医院,邯郸 056001邯郸市中医院,邯郸 056001邯郸市中医院,邯郸 056001邯郸市中医院,邯郸 056001邯郸市中医院,邯郸 056001邯郸市中医院,邯郸 056001
医药卫生
针刺疗法针药并用质子泵抑制剂胃食管反流胃动素生长激素释放肽
Acupuncture therapyAcupuncture medication combinedProton pump inhibitorsGastroesophageal reflux diseaseMotilinGrowth hormone-releasing peptide
《上海针灸杂志》 2026 (5)
491-496,6
河北省中医药管理局科研计划项目(2019381)
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