基于气液-玄府-浊毒理论探讨慢性肾脏病相关性皮肤瘙痒的诊治思路OA

This paper reviews the development and interrelationships of the theories of qi fluid-sweat pore-turbid toxin,and discusses their relevance to the disease mechanism of chronic kidney disease-associated pruritus(CKD-aP).It is proposed that disharmony of qi and fluid in the kidney often contributes to the development of chronic kidney disease(CKD);sweat pore stagnation resulting from this disharmony constitutes an intermediate link in the development of CKD-aP;and the diffusion of turbid evil to the skin due to sweat pore obstruction is the direct cause of CKD-aP.In treatment,methods such as tonifying deficiency,dispelling wind,clearing heat,resolving phlegm,and promoting blood circulation are used to open the sweat pore,and correspondingly therapeutic approaches that moisten dryness,dispel pathogenic factors,remove toxin,eliminate dampness,and unblock the collaterals are applied to relieve itching.Commonly used formulas include Jinkui Shenqi pill(金匮肾气丸),Guizhi Mahuang Geban decoction(桂枝麻黄各半汤),Yinqiao powder(银翘散),Wuwei Xiaodu beverage(五味消毒饮),Erchen decoction(二陈汤),and Xuefu Zhuyu decoction(血府逐瘀汤).This theoretical framework is expected to provide a basis for the clinical treatment of CKD-aP.