微创穴位埋线疗法治疗围绝经期综合征的疗效和机制探讨OA
Discussion on the efficacy and mechanism of minimally invasive acupoint catgut embedding therapy for perimenopausal syndrome
目的 评价微创穴位埋线疗法治疗围绝经期综合征的疗效和安全性.方法 将 66 例围绝经期综合征患者随机分为治疗组和对照组,每组各33例.治疗组予穴位埋线治疗,对照组予芬吗通口服.两组于治疗前、治疗1月、2 月、3 月分别用改良的 Kupperman 指数评分法进行症状评分,并测定两组治疗前后血清性激素水平,比较两组临床疗效及不良反应发生率.结果 两组患者治疗前、治疗 1 月、2 月、3 月症状评分逐渐降低(P<0.05);治疗组在治疗 1 月和 2 月评分高于对照组(P<0.05),但在治疗 3 月评分差异无统计学意义(P>0.05).相较于治疗前,两组患者治疗后的血清雌二醇水平均增加(P<0.05)、黄体生成素和卵泡刺激素水平均降低(P<0.05);治疗后两组性激素水平差异均无统计学意义(P>0.05).治疗组在治疗 1 月后、治疗 2 月后其总有效率分别为 50.00%、66.67%,低于对照组的 73.33%,83.33%(P<0.05),但在治疗 3 个月后,治疗组的总有效率(90.00%)和对照组总有效率(86.67%)差异无统计学意义(P>0.05).治疗结束后,治疗组、对照组不良反应发生率分别为 3.33%、30.00%,治疗组明显低于对照组(P<0.05).结论 微创穴位埋线疗法可以明显改善围绝经期综合征患者症状,改善其性激素水平,且不良反应发生率低,值得临床推广应用.
Objective To evaluate the efficacy and safety of minimally invasive acupoint catgut embedding therapy in the treatment of perimenopausal syndrome.Methods A total of 66 patients with perimenopausal syndrome were randomly divided into a treatment group and a control group,with 33 cases in each group.The treatment group was given acupoint catgut embedding therapy,while the control group was given oral Femoston.The modified Kupperman index scoring method was used to evaluate symptom scores in both groups before treatment and at the 1st,the 2nd,and the 3rd months after treatment.Serum sex hormone levels were measured before and after treatment,and the clinical efficacy and incidence of adverse reactions were compared between the two groups.Results The symptom scores of both groups gradually decreased before treatment and at the 1st,the 2nd,and the 3rd months after treatment(P<0.05).The scores of the treatment group were higher than those of the control group at the 1st and the 2nd months after treatment(P<0.05),but there was no statistically significant difference at the 3rd month after treatment(P>0.05).Compared with pre-treatment levels,the serum estradiol levels in both groups increased after treatment(P<0.05),while the levels of luteinizing hormone and follicle-stimulating hormone decreased(P<0.05).There was no statistically significant difference in sex hormone levels between the two groups after treatment(P>0.05).The total effective rates of the treatment group at the 1st and the 2nd months after treatment were 50.00%and 66.67%,respectively,which were lower than 73.33%and 83.33%of the control group(P<0.05).However,at the 3rd months after treatment,there was no statistically significant difference in the total effective rate between the treatment group(90.00%)and the control group(86.67%)(P>0.05).After treatment,the incidence of adverse reactions in the treatment group and the control group was 3.33%and 30.00%,respectively,with the treatment group being significantly lower than the control group(P<0.05).Conclusion Minimally invasive acupoint catgut embedding therapy can significantly improve the symptoms of patients with perimenopausal syndrome and regulate their sex hormone levels,with a low incidence of adverse reactions,which is worthy of clinical promotion and application.
杨春英;代利利
江苏大学附属医院,江苏 镇江 212000江苏大学附属医院,江苏 镇江 212000
医药卫生
围绝经期综合征穴位埋线改良 Kupperman 评分性激素水平
Perimenopausal syndromeAcupoint catgut embeddingModified Kupperman scoreSex hormone level
《四川中医》 2026 (5)
59-65,7
江苏省妇幼健康研究会委托研究课题(JSFY202303).
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