同步辐射小角散射技术在化妆品纳米结构表征中的应用与挑战OA

Cosmetic products encompass a broad range of categories,including sunscreens,personal care products,and color cosmetics.These products are typically multiphase soft matter systems composed of multiple components with complicated interactions.Their interior commonly contains entities with spatial scale from 1 to 100 nm,including lamellar liquid crystals,vesicles,micelles,microemulsions,nanoparticles,and weakly interacting networks formed by these entities.Such nanostructures play a decisive role in stability,sensory properties,delivery behavior,and overall efficacy of cosmetic products.Small-angle X-ray scattering(SAXS)enables in-situ and ensemble-averaged structural characterization of nanoscale structures under non-destructive conditions in real formulations and actual application states.Therefore,SAXS has now become an essential structural characterization tool throughout cosmetic formulation design,process optimization and scale-up,quality control,consistency evaluation,and structure-function relationship research.In this review,both recent academic and industrial progresses of SAXS for characterizing cosmetic nanostructures were summarized.Representative applications and case studies of SAXS in typical cosmetic systems were systematically discussed.Furthermore,current opportunities and challenges in the aspects of data interpretation in complex multi-component systems,including modeling strategies and result interpretability,were critically analyzed.The potential of BioSAXS beamline BL19U2 at the Shanghai Synchrotron Radiation Facility(SSRF)to empower cosmetic research was also discussed.Finally,considering the emerging trends in artificial intelligence-driven data analysis and multimodal structural characterization,the prospects for SAXS applications in the rational design of cosmetic formulations and the mechanism studies of efficacy were discussed.