仿纤维素酶固体酸催化剂结合域设计与研究进展OA

The dense crystalline structure and limited accessibility of cellulose severely hinder its efficient catalytic conversion.In response,biomimetic solid acid catalysts inspired by cellulase binding domains(CBDs)have emerged as a promising strategy to enhance cellulose hydrolysis by mimicking the substrate recognition and enrichment functions of natural enzymes.This review systematically summarizes recent advances in the design of CBD-mimetic solid acids based on four representative strategies:electrostatic anchoring,hydrophobic microenvironment engineering,spatial confinement and covalent lock-and-key mechanisms.The underlying principles of these approaches,including substrate-specific recognition,local concentration enhancement,and synergistic"adsorption-catalysis"effects,are critically discussed to elucidate their contributions in improving catalytic affinity,selectivity,and durability.Despite significant progress,challenges such as mass-transfer resistance and insufficient structural robustness remain in complex biomass conversion systems.Looking forward,the integration of sub-enzymatic materials,such as carbon quantum dots(CQDs),into biomimetic catalysts offers new opportunities to achieve efficient,recyclable and hierarchically organized catalytic systems,thereby providing a powerful route for the sustainable valorization of cellulose and other lignocellulosic resources.