葛根抗衰老及其相关疾病的研究进展OA

As a Medicinal and edible herb in China,Pueraria lobata has s a long history of medicinal and dietary application.Modern pharmacological research identified its bioactive compounds,including isoflavonoids(puerarin,daidzein,and genistein),polysaccharides,proteins,and other constituents.These components demonstrate significant anti-aging pharmacological activities,including anti-inflammatory,antioxidant,autophagy regulation,and improvement of mitochondrial function.This review systematically summarizes the core molecular mechanisms of Pueraria lobata and its active constituents in delaying the aging process and preventing aging-related diseases,particularly in counteracting oxidative stress and inflammatory responses,regulating autophagy,and enhancing mitochondrial function.This review provides an in-depth analysis of the"multi-component-multi-target-multi-pathway"synergistic anti-aging pharmacological effect of Pueraria lobata.Under the circumstance of population aging,this review provides a reference for the application of Pueraria lobata in age-related diseases and the development of anti-aging products.