红藤-败酱草药对及其活性成分治疗盆腔炎性疾病后遗症作用机制研究OA

Sequelae of pelvic inflammatory disease(SPID)is a chronic pathological condition resulting from prolonged or recurrent pelvic inflammatory disease(PID).In traditional Chinese medicine(TCM),dampness-heat and blood stasis are considered the key pathogenesis of SPID.The herb pair Hongteng(Sargentodoxae Caulis)-Baijiangcao(Herba Patriniae),which embodies the therapeutic principle of"clearing heat-toxin,removing dampness,and resolving stasis"plays a multi-target and multi-pathway regulatory role in treating SPID.This article reviews recent clinical and experimental studies on this herb pair and systematically summarizes its active components and mechanisms.It demonstrates that the herb pair exerts synergistic effects through anti-inflammatory immunomodulation,antioxidative stress,anti-fibrosis,tissue repair,and improvement of hemorheology.Specifically,components such as quercetin and luteolin inhibit signaling pathways like NF-κB and PI3K/Akt,reduce levels of inflammatory factors including TNF-α and IL-6,modulate macrophage polarization,and restore immune homeostasis.Emodin and salidroside alleviate oxidative damage by activating the Nrf2/HO-1 pathway,enhancing SOD activity,and reducing MDA content.In terms of inhibiting fibrosis,luteolin and procyanidins interfere with the TGF-β1/Smad and Hippo/YAP signaling pathways,reduce extracellular matrix deposition,and delay pathological progression.Additionally,quercetin and chlorogenic acid inhibit platelet aggregation and regulate vascular activity,thereby improving pelvic microcirculation.This review summarizes recent advances in the study of active components and mechanisms of Hongteng(Sargentodoxae Caulis)and Baijiangcao(Herba Patriniae),providing a theoretical foundation for further exploration of their clinical application.