自拟中药复方联合火针放血治疗囊肿型痤疮的临床疗效OA
Clinical study on the efficacy of self-formulated traditional Chinese medicine compound decoction combined with fire needle bloodletting in the treatment of cystic acne
目的 探讨自拟中药复方联合火针放血治疗囊肿型痤疮的临床疗效.方法 选择2023年1月—2025年3月我院收治的80例囊肿型痤疮患者作为研究对象,随机分为对照组(n=40)和观察组(n=40).对照组采用口服异维A酸胶囊联合火针放血治疗,观察组采用自拟中药复方联合火针放血治疗.比较两组治疗后的临床总有效率、不同时间点(治疗前及治疗7、14、28 d后)的皮损积分、皮肤病生活质量指数(DLQI)评分、血清炎症因子(TNF-α、CRP、IL-6、IL-1β)水平及面部皮肤油脂含量.采用广义估计方程模型分析皮损积分和DLQI评分的时间效应与组间效应;比较两组治疗期间不良反应发生率.结果 观察组临床总有效率为95.00％,显著高于对照组的75.00％,差异有统计学意义(x2=5.17,P=0.023).治疗后各时间点,两组皮损积分、炎症因子水平及油脂含量均较治疗前显著降低(P＜0.05),DLQI评分显著升高(P＜0.05);观察组在上述指标的改善程度上均优于对照组(P＜0.05).广义估计方程分析显示,时间与分组对皮损积分和DLQI评分存在显著的交互效应(P＜0.001).观察组不良反应总发生率为7.50％,显著低于对照组的25.00％(x2=4.50,P=0.034).结论 自拟中药复方联合火针放血治疗囊肿型痤疮,可有效减轻皮损、改善患者生活质量、降低炎症水平及皮脂分泌,且安全性优于口服异维A酸联合火针方案,具有一定的临床推广价值.
Objective To evaluate the clinical efficacy of self-formulated traditional Chinese medicine compound decoction combined with fire needle bloodletting in treating cystic acne.Methods Eighty patients with cystic acne admitted to our hospital from January 2023 to March 2025 were enrolled and randomly divided into a control group(n=40)and an observation group(n=40).The control group was treated with oral isotretinoin capsules combined with fire needle bloodletting therapy,while the observation group received the self-formulated traditional Chinese medicine compound decoction combined with fire needle bloodletting therapy.The total clinical ef-fective rates,skin lesion scores,Dermatology life quality index scores,serum inflammatory factor levels(TNF-α,CRP,IL-6,IL-1β),and facial sebum content were compared between the two groups before and after 7,14,and 28 days of treatment.A generalized estimating equation model was used to analyze the time and group effects on skin lesion scores and DLQI scores.The inci-dence of adverse reactions during the treatment was compared between the two groups.Results The total clinical effective rate was significantly higher in the observation group than in the control group(95.00％vs.75.00％,x2=5.17,P=0.023).At all post-treatment time points,skin le-sion scores,inflammatory factor levels,and sebum content significantly decreased(P＜0.05),while DLQI scores significantly increased(P＜0.05)compared with baseline in both groups.The observation group demonstrated greater improvement than the control group on all indices(P＜0.05).The Generalized Estimating Equation analysis revealed significant interaction effects between time and group on both skin lesion scores and DLQI scores(P＜0.001).The total inci-dence of adverse reactions in the observation group was significantly lower than that in the control group(7.50％vs.25.00％,x2=4.50,P=0.034).Conclusions The combination of tradition-al Chinese medicine compound decoction and fire needle bloodletting is effective in reducing skin lesions,improving quality of life,lowering inflammatory levels,and decreasing sebum secretion in patients with cystic acne.Furthermore,it demonstrates a better safety profile compared to the combination of oral isotretinoin and fire needle bloodletting,suggesting its potential for clinical ap-plication.
焦建霞;赵艳君;赵玉;陈晓
上海市青浦区中医医院,上海 201799上海市青浦区中医医院,上海 201799上海市青浦区中医医院,上海 201799上海市青浦区中医医院,上海 201799
囊肿型痤疮中药复方火针放血治疗
cystic acnetraditional Chinese medicine compound decoctionfire needlebloodletting therapy
《皮肤性病诊疗学杂志》 2026 (4)
262-270,9
上海卫生健康委员会科技项目(2023KFY034)
评论