HIV感染合并肺癌患者的临床病理学特征及免疫状态分析OA

Objective To investigate the clinicopathological characteristics of patients with HIV infection and lung cancer and their relationship with peripheral immune status.Methods A retrospective analysis was performed on the clinicpathological data of 51 patients with HIV infection and lung cancer.Immunohistochemistry(IHC)was conducted to detect the expression of CK7,TTF-1,p40,Syn,Ki67 and other proteins in each group.Flow cytometry was used to measure peripheral blood CD4+and CD8+T-cell counts,and the CD4+/CD8+ratio was calculated to analyze its association with pathological subtypes and immunophenotypes.Results The main pathological types were adeno-carcinoma(56.9%)and squamous cell carcinoma(35.3%).The Ki67 proliferation index was significantly higher in squamous cell carcinoma than in adenocarcinoma(P<0.05),and the CD4+/CD8+ratio was significantly lower(median 0.39 vs 0.72,P<0.05).Patients with CK7 negative expression also showed a significantly lower CD4+/CD8+ratio compared to those with CK7 positivity(P<0.05).ROC curve analysis indicated that the CD4+/CD8+ratio had moder-ate diagnostic value for predicting squamous cell carcinoma(AUC=0.732 8).At the optimal cutoff value of 0.611 1,the sensitivity and specificity were 61.11%and 82.76%,respectively.Conclusion There appears to be an associa-tion between the pathological type and peripheral immune status in patients with HIV infection and lung cancer.The CD4+/CD8+ratio may serve as a potential indicator reflecting immune function and tumor subtype,suggesting its poten-tial clinical utility in the evaluation and differential diagnosis of HIV infection-associated lung cancer.