肺结节患者预后影响因素的系统评价和Meta分析OA

Objective To investigate the effects of different influencing factors on the prognosis of patients with pulmonary nodules,and to provide a scientific basis for clinical diagnosis and treatment.Methods Cohort studies and case-control studies with different influencing factors of prognosis of patients with pulmonary nodules were collected from China National Knowledge Infrastructure,China Biomedical Literature Service System,PubMed,Cochrane Library,Embase,and Web of Science databases,and the search period was from March 1,2024 to February 29,2024.The study was conducted using Revman5.3 and Stata18,and relevant data were extracted,including WMD,OR,95%CI.Results A total of 13 studies were conducted,involving 4 011 study subjects.The results of Meta-analysis showed that age(WMD=-5.35,P<0.001,I 2=82%),family history(OR=0.03,P<0.001,I 2=97%),smoking history(OR=0.18,P<0.001,I 2=95%),nodule location(OR=1.98,P<0.001,I 2=87%),nodule diameter(WMD=-2.13,P<0.001,I 2=42%),lobulation signs(OR=1.53,P=0.003,I 2=97%),cavitation signs(OR=33.71,P<0.001,I 2=99%),spiculation sign(OR=2.32,P<0.001,I 2=95%),vacuole signs(OR=0.54,P<0.001,I 2=99%),neuron-specific enolase(WMD=-1.25,P<0.001,I 2=74%)were the influencing factors for poor prognosis in patients with pulmonary nodules(P<0.05).Conclusion The prognosis of patients with pulmonary nodules is associated with ad-vanced age,family histo-ry,smoking history,nodules located in the upper lobes,large nodule diameter,and the presence of lobulation,cavitation,spiculation or vacuole signs,as well as elevated neuron-specific enolase.