NLR、PLR和SII对三阴性乳腺癌患者根治术后复发转移的预测价值OA
Predictive value of NLR,PLR and SII for recurrence and metastasis after radical surgery in patients with triple-negative breast cancer
目的 探讨炎症复合指标[中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、系统性免疫炎症指数(SII)]对三阴性乳腺癌(TNBC)患者根治术后复发转移的预测价值.方法 选取2022年1月至2024年3月佳木斯市中心医院收治的170例女性TNBC患者作为研究对象,术后通过门诊随访 2年,根据随访期间是否复发转移将患者分为复发转移组(发生复发转移)与未复发转移组(未发生复发转移).收集并比较患者基线资料,术前检测中性粒细胞计数、淋巴细胞计数及血小板计数并计算NLR、PLR、SII;采用Cox回归分析TNBC患者根治术后复发转移的影响因素;绘制受试者工作特征(ROC)曲线分析 NLR、PLR、SII对TNBC患者根治术后复发转移的预测效能.结果 复发转移组53例,未复发转移组117例.复发转移组NLR、PLR、SII及TNM 分期Ⅲ期比例、有淋巴结转移比例均高于未复发转移组(P<0.001).多因素Cox回归分析结果显示:TNM 分期Ⅲ期、有淋巴结转移及 NLR、PLR、SII升高均是 TNBC患者根治术后复发转移的危险因素(P<0.05).ROC曲线分析结果显示:NLR、PLR、SII单独及3项联合预测患者根治术后复发转移的曲线下面积(AUC)分别为0.694、0.722、0.735、0.847,3项联合预测的 AUC大于 NLR、PLR、SII单独预测(Z=2.952、2.623、1.969,均P<0.05).结论 TNBC患者 NLR、PLR、SII升高是 TNBC患者根治术后复发转移的危险因素,3项联合对于TNBC患者根治术后复发转移具有较高的预测价值.
Objective To investigate the predictive value of inflammatory composite indicators[neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),systemic immune-inflammation index(SII)]for postoperative recurrence and metastasis in the patients with triple-negative breast cancer(TNBC).Meth-ods A total of 170 female TNBC patients admitted and treated in Jiamusi Municipal Central Hospital from January 2022 to March 2024 were selected as the study subjects.The postoperative follow-up was conducted through outpatient reexamination for 2 years.According to whether the recurrence or metastasis occurred dur-ing the follow-up period,the patients were divided into the recurrence and metastasis group(recurrence or me-tastasis occurrence)and non-recurrence and metastasis group(without recurrence or metastasis occurrence).The baseline data of the patients were collected and compared.The neutrophil count,lymphocyte count and platelet count were detected before operation.The NLR,PLR and SII were calculated.The Cox regression was used to analyze the influencing factors of the recurrence and metastasis after radical surgery in TNBC pa-tients.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive efficiency of the NLR,PLR and SII for the recurrence and metastasis after radical surgery in TNBC patients.Results There were 53 cases in the recurrence and metastasis group and 117 cases in the non-recurrence and metastasis group.The proportions of NLR,PLR,SII and TNM stage Ⅲ,and lymph node metastasis in the recurrence and metastasis group were all higher than those in the non-recurrence and metastasis group(P<0.001).The Cox regression analysis results showed that the TNM stage Ⅲ,lymph node metastasis and increased NLR,PLR and SII all were the risk factors for recurrence and metastasis after radical surgery in TNBC patients(P<0.05).The ROC curve analysis results showed that the areas under curves(AUCs)of NLR,PLR and SII alone and 3-item combination for predicting recurrence and metastasis after radical operation in TNBC patients were 0.694,0.722,0.735 and 0.847,respectively,the AUC of the 3-item combination prediction was greater than that of NLR,PLR SII alone(Z=2.952,2.623,1.969;P<0.05).Conclusion The increased NLR,PLR and SII are the risk factors for recurrence and metastasis after radical surgery in TNBC patients,and the 3-item combina-tion has a higher predictive value for recurrence and metastasis after radical surgery in TNBC patients.
丁典;李冠林;廉奇鑫
黑龙江省佳木斯市中心医院肿瘤科,黑龙江 佳木斯 154002南方医科大学第二临床医学院顺德校区,广东 佛山 528305佳木斯大学临床医学院,黑龙江 佳木斯 154003
医药卫生
三阴性乳腺癌中性粒细胞与淋巴细胞比值血小板与淋巴细胞比值系统性免疫炎症指数复发转移预测
triple-negative breast cancerneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte rati-osystemic immune inflammation indexrecurrence and metastasisprediction
《检验医学与临床》 2026 (10)
1365-1370,6
黑龙江省卫生健康委科研课题(20230404080178).
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