血清FSTL1、CyPA对2型糖尿病患者并发颈动脉粥样硬化的诊断价值OA

Objective To explore the diagnostic value of serum follicle-stimulating hormone-like protein-1(FSTL1)and cyclophilin A(CyPA)for carotid atherosclerosis in patients with type 2 diabetes mellitus(T2DM).Methods A total of 78 T2DM patients with carotid atherosclerosis who were treated in the hospital from October 2021 to October 2024 were selected as the occurrence group.According to the degree of athero-sclerosis,T2DM patients with carotid atherosclerosis were divided into arterial plaque group and primary thickening group,and another 61 T2DM patients without carotid atherosclerosis who were treated in the hos-pital during the same period were selected as the simple T2DM group.Baseline data of the enrolled patients were collected,and serum FSTL1 and CyPA levels were detected.Point-biserial correlation analysis was used to analyze the correlation between serum FSTL1 and CyPA levels and the degree of carotid atherosclerosis of T2DM patients with carotid atherosclerosis.Pearson correlation analysis was used to analyze the correlation between serum FSTL1 level and CyPA level of T2DM patients with carotid atherosclerosis.Multivariate Lo-gistic analysis was used to analyze the influencing factors of T2DM patients with carotid atherosclerosis.Re-ceiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum FSTL1 and CyPA for T2DM patients with carotid atherosclerosis.Results The disease duration of the occurrence group was longer than that of the simple T2DM group,and the levels of low-density lipoprotein cholesterol,fasting blood glucose and homocysteine were higher than those of the simple T2DM group,and the differences were statistically significant(P＜0.05).The serum FSTL1 and CyPA levels of the occurrence group were higher than those of the simple T2DM group,and the differences were statistically significant(P＜0.05).The serum FSTL1 and CyPA levels of the arterial plaque group were higher than those of the primary thickening group,and the differences were statistically significant(P＜0.05).The point-biserial correlation analysis showed that the serum FSTL1 and CyPA levels of T2DM patients with carotid atherosclerosis were positively correlated with the degree of carotid atherosclerosis(r=0.621,0.567,both P＜0.05).The Pearson correlation analysis showed that the serum FSTL1 level of T2DM patients with carotid atherosclerosis was positively correlated with the CyPA level(r=0.400,P＜0.001).The results of multivariate Logistic regression analysis showed that the prolongation of T2DM duration and the elevation of FSTL1,CyPA,fasting blood glucose and homo-cysteine levels were risk factors for T2DM complicated with carotid atherosclerosis(P＜0.05).The ROC curve analysis results showed that the area under the curve(AUC)of serum FSTL1 and CyPA combined for diagnosing T2DM patients complicated with carotid atherosclerosis was 0.930,which was greater than the AUC of serum FSTL1 and CyPA alone(ZFSTL1=2.238,PFSTL1=0.025;ZCyPA=3.072,PCyPA=0.002).Conclusion The serum levels of FSTL1 and CyPA in patients with T2DM complicated with carotid athero-sclerosis are eevated,and they are closely related to the degree of arteriosclerosis.The combined detection of FSTL1 and CyPA has a higher diagnostic efficacy for T2DM patients complicated with carotid atherosclerosis.