超敏C反应蛋白与精神分裂症患者认知功能的关联:MCCB的横断面研究OA

Objective:To evaluate multidomain cognitive function in patients with schizophrenia using the MAT-RICS Consensus Cognitive Battery(MCCB)and to explore the association between serum high-sensitivity C-reac-tive protein(hs-CRP)levels and cognition function as well as gender differences.Methods:A total of 160 clinically stable inpatients with schizophrenia were consecutively recruited from October 2024 to July 2025 at the Mental Health Center,Zhejiang University School of Medicine.Cognitive function was assessed with the MCCB,serum hs-CRP was measured by chemiluminescence,and psychiatric symptoms were evaluated with the Positive and Negative Syndrome Scale(PANSS).Demographic and clinical variables were collected.Independent-sample t-tests,Mann-Whitney U test,x2 test,Spearman correlations,and multivariable linear regression models(adjusting for age,sex,years of education,body mass index[BMI],illness duration,PANSS scores,and antipsychotic dose)were used to ex-amine the relationships between hs-CRP and cognition,as well as gender stratification and interaction tests were conducted.Results:Among 160 participants,51(31.9％)were in the high hs-CRP group(≥3 mg/L)and 109(68.1％)in the low group(＜3 mg/L).BMI differed significantly between groups(t=-0.664,P=0.039).Spearman analyses showed significant negative correlations between hs-CRP and the MCCB composite score as well as pro-cessing speed,attention/vigilance,working memory,visual learning,and social cognition(r=-0.157 to-0.252;P＜0.05).After adjustment,ln-hsCRP remained independently associated with the MCCB composite(β=-0.214,P=0.003),visual learning(β=-0.231,P=0.004),and social cognition(β=-0.235,P=0.005).In sex-stratified analy-ses,ln-hsCRP was negatively associated with the MCCB composite(β=-0.279,P=0.021)and visual learning(β=-0.304,P=0.013)in males,and with social cognition(β=-0.244,P=0.029)in females;however,no significant sex × hs-CRP interaction effects were observed(P＞0.05).Conclusion:Elevated serum hs-CRP levels are significantly associated with cognitive impairment in patients with schizophrenia,particularly in visual learning and social cogni-tion.Different patterns are observed between sexes,with males more affect in overall cognition and visual learning,and females mainly in social cognition,although no significant interaction is detected.These findings suggest that in-flammation may represent an important biological mechanism underlying cognitive deficits in schizophrenia and may serve as a potential target for clinical assessment and intervention.