精神分裂症患者阴性症状与日常生活能力的关系:认知功能的中介作用OA

Objective:To investigate the mediating role of cognitive function between negative symptoms and daily living ability in patients with schizophrenia.Methods:A total of 106 patients were assessed using the PANSS negative subscale,MoCA,and ADL scale.Mediation analysis(PROCESS Model 4)was conducted while controlling for gender,age,disease duration,education level,positive symptoms,and general psychopathology.Results:Cognitive function scores were notably impaired(16.57±4.92).Negative symptoms correlated negatively with MoCA scores(r=-0.47,P＜0.01)and positively with ADL scores(r=0.36,P＜0.01),while MoCA and ADL scores showed a negative corre-lation(r=-0.45,P＜0.01).Mediation analysis revealed a significant total effect of negative symptoms on ADL(β=0.358,P＜0.01),with a direct effect of β=0.264(95％CI[0.042,0.487],73.74％of total effect)and an indirect effect mediated by cognitive function(β=0.094,95％CI[0.017,0.210],26.26％of total effect).Conclusion:Cognitive function partially mediates the relationship between negative symptoms and daily living ability,highlighting the need for cognitive rehabilitation alongside symptom management to improve functional outcomes in schizophrenia.