葛根芩连汤联合双歧杆菌三联活菌胶囊防治腹部及盆腔恶性肿瘤放射性肠炎的临床效果OA
Clinical effect of Gegen Qinlian Decoction combined with Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules on preventing and treating radiation enteritis of abdominal and pelvic malignant tumors
目的 探讨葛根芩连汤联合双歧杆菌三联活菌胶囊防治腹部及盆腔恶性肿瘤放射性肠炎(RE)的临床效果.方法 选取 2023 年 1 月至 2024 年 12 月九江市第一人民医院收治的 80 例腹部及盆腔放疗恶性肿瘤患者作为研究对象,按照随机数字表法分为双歧杆菌三联胶囊单药组和双药联合组,每组 40 例.放疗前 1 d,双歧杆菌三联胶囊单药组给予双歧杆菌三联胶囊治疗,双药联合组给予葛根芩连汤联合双歧杆菌三联胶治疗,比较两组患者急性放射性损伤分级和放射性肠炎发生率,比较两组患者放疗前 1 d和放疗 3 个月后的中医症状积分、炎症指标[(白介素-6(IL-6)、血清超敏 C 反应蛋白(hs-CRP)]和免疫功能指标[免疫球蛋白 G(IgG)、免疫球蛋白 A(IgA)及免疫球蛋白 M(IgM)]变化.结果 双药联合组的放射肿瘤协作组(RTOG)分级优于双歧杆菌三联胶囊单药组,RE发生率低于双歧杆菌三联胶囊单药组,差异均有统计学意义(P＜0.05).放疗 3 个月后,两组患者 7 项中医症状积分均低于本组放疗前 1 d,双药联合组 7 项中医症状积分低于双歧杆菌三联胶囊单药组,差异有统计学意义(P＜0.05).放疗 3 个月后,两组患者血清 IL-6、hs-CRP 水平低于本组放疗前 1 d,血清 IgG、IgA 及 IgM 水平高于本组放疗前 1 d,双药联合组血清 IL-6、hs-CRP 水平低于双歧杆菌三联胶囊单药组,血清 IgG、IgA 及 IgM 水高于双歧杆菌三联胶囊单药组,差异有统计学意义(P＜0.05).结论 葛根芩连汤联合双歧杆菌三联活菌胶囊用于腹部及盆腔恶性肿瘤患者,能有效改善急性放射性损伤,降低 RE 发生风险,缓解患者中医相关症状,减轻患者炎症反应,提高其免疫功能.
Objective To explore the clinical efficacy of Gegen Keminlia n Decoction combined with Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules in preventing radiation enteritis(RE)in patients with abdominal and pelvic malignant tumors.Methods A total of 80 patients with abdominal and pelvic malignant tumors who received radiotherapy at Jiujiang NO.1 People's Hospital from January 2023 to December 2024 were selected as the research subjects,they were divided into the single Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules group and the dual drug combination group,with 40 cases in each group.One day before radiotherapy,the single Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules group was treated with Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules,and the dual drug combination group was treated with Gegen Qinlian Decoction combined with Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules.The acute radiation injury grading and the incidence of RE were compared between the two groups.The changes in the Chinese medicine symptom scores,inflammatory indicators(interleukin-6[IL-6],serum high-sensitivity C-reactive protein[hs-CRP]),and immune function indicators(immunoglobulin G[IgG],immunoglobulin A[IgA],and immunoglobulin M[IgM])before radiotherapy and 3 months after radiotherapy were compared between the two groups.Results The Radiation Therapy Oncology Group(RTOG)grading of the dual drug combination group was better than that of the single Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules group,and the incidence of RE was lower than that of the single Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules group,with statistically significant differences(P＜0.05).Three months after radiotherapy,the 7 Chinese medicine symptom scores of both groups were lower than those 1 d before radiotherapy,and the 7 Chinese medicine symptom scores of the dual drug combination group were lower than those of the single Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules group,with statistically significant differences(P＜0.05).Three months after radiotherapy,the levels of serum IL-6,hs-CRP of both groups were lower than those 1 d before radiotherapy,and the levels of serum IgG,IgA,and IgM were higher than those 1 d before radiotherapy,the levels of serum IL-6,hs-CRP in the dual drug combination group were lower than those in the single Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules group,and the levels of serum IgG,IgA,and IgM were higher than those in the single Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules group,with statistically significant differences(P＜0.05).Conclusion Gegen Keminlian Decoction combined with Live Combined Bifidobacterium,Lactobacillus and Enterococcus Capsules can effectively improve acute radiation injury,reduce the risk of RE,alleviate Chinese medicine-related symptoms,alleviate inflammatory responses,and improve immune function in patients with abdominal and pelvic malignant tumors.
叶威;肖喜凤;曾灵芝;王璐
江西省九江市第一人民医院放疗室,江西 九江 332000江西省九江市第一人民医院消化内科,江西 九江 332000江西省九江市第一人民医院肿瘤内科,江西 九江 332000江西省九江市第一人民医院肿瘤内科,江西 九江 332000
医药卫生
葛根芩连汤双歧杆菌三联活菌胶囊放射性肠炎中医相关症状炎症反应免疫功能
Gegen Qinlian DecoctionLive Combined Bifidobacterium,Lactobacillus and Enterococcus CapsulesRadia-tion enteritisTraditional Chinese medicine-related symptomsInflammatory responseImmune function
《中国当代医药》 2026 (10)
34-37,43,5
江西省中医药管理局科技计划项目(2024B0504)江西省九江市科技计划项目(2025_000358).
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