靶向自噬调控消化道肿瘤化疗耐药性的研究进展OA

Chemotherapy is a common treatment for cancer;however,its efficacy is often significantly limited by the development of drug resistance.Gastrointestinal tumors are among the most common malignancies worldwide,and overcoming chemoresistance is crucial for improving patient prognosis.Autophagy,a catabolic process that maintains cellular homeostasis,plays a dual role in the drug resistance of gastrointestinal tumors.On one hand,protective autophagy contributes to the development of chemoresistance;on the other hand,excessive or sustained autophagy may induce autophagic cell death,thereby reversing drug resistance.Therefore,the targeted modulation of autophagy has emerged as a promising strategy to counteract chemoresistance.This review begins with an overview of the classification and fundamental processes of autophagy,systematically elucidates its bidirectional regulatory function in gastrointestinal tumor chemoresistance,and summarizes recent advances in targeting autophagy via autophagy inhibitors or activators to overcome chemoresistance,aiming to provide new insights and rationale for anticancer therapy in gastrointestinal tumors.