miR-141在恶性肿瘤诊断、预后及靶向治疗中的作用研究进展OA
Research progress on the role of miR-141 in the diagnosis,prognosis,and targeted therapy of malignant tumors
微小RNA(miRNA)是一类18～25个核苷酸的小分子非编码RNA,可通过调控靶基因表达参与细胞增殖、分化及凋亡等生物学过程.miR-141作为关键的肿瘤抑制性miRNA,在多种恶性肿瘤的发生与进展中发挥核心调控作用,其可直接靶向锌指E盒结合同源框(ZEB)1/2、第10号染色体缺失的磷酸酶及张力蛋白同源物(PTEN)及B细胞特异性莫洛尼鼠白血病病毒插入位点1(BMI1)等关键分子,调控上皮-间质转化(EMT),PTEN/蛋白激酶B-糖原合成激酶3β(Akt-GSK3β)及Wnt/β-连环蛋白(Wnt/β-catenin)信号通路,进而抑制恶性肿瘤细胞增殖、促进恶性肿瘤细胞凋亡,阻断肿瘤侵袭转移及血管生成,全程参与恶性肿瘤发生发展的调控进程.miR-141不仅有望成为恶性肿瘤早期诊断与预后评估的潜在分子标志物,为精准诊疗提供新方向,还可作为治疗靶点,恢复其表达可提升化疗及靶向药物治疗的疗效,改善患者的预后.本文就miR-141在恶性肿瘤诊断、预后及靶向治疗中的作用研究进展进行综述,旨在为恶性肿瘤的临床治疗提供参考.
MicroRNAs(miRNAs)are a class of small non-coding RNAs consisting of 18-25 nucleotides that participate in various biological processes,including cell proliferation,differentiation,and apoptosis,by regulating the expression of target genes.As a key tumor-suppressive miRNA,miR-141 plays a central regulatory role in the occurrence and progression of multiple malignant tumors.It can directly target key molecules such as zinc finger E-box-binding homeobox 1/2(ZEB1/2),phosphatase and tensin homolog deleted on chromosome 10(PTEN),and B-cell-specific moloney murine leukemia virus insertion site 1(BMI1),and regulate signaling pathways including epithelial-mesenchymal transition(EMT),PTEN/protein kinase B-glycogen synthase kinase 3β(Akt-GSK3β),and Wnt/β-catenin.Through these mechanisms,miR-141 inhibits the proliferation of malignant tumor cells,promotes apoptosis,and blocks their invasion,metastasis,and angiogenesis,participating in the entire regulatory process of the occurrence and development of malignant tumors.miR-141 is expected not only to serve as a potential molecular biomarker for early diagnosis and prognosis evaluation of malignant tumors,providing new directions for precise diagnosis and treatment,but also to act as a therapeutic target,restoring its expression can enhance the efficacy of chemotherapy and targeted drugs and improve patient prognosis.This review summarizes the research progress of miR-141 in the diagnosis,prognosis,and targeted therapy of malignant tumors,aiming to provide a reference for the clinical treatment of malignant tumors.
马玉嫆;张敏;王康乐;孙田思;陈璇羽;王欣怡;王波波;王逢会
延安大学医学院基础医学院,陕西 延安 716000延安大学医学院基础医学院,陕西 延安 716000延安大学医学院基础医学院,陕西 延安 716000延安大学医学院基础医学院,陕西 延安 716000延安大学医学院基础医学院,陕西 延安 716000延安大学医学院基础医学院,陕西 延安 716000延安大学医学院基础医学院,陕西 延安 716000||延安市动物及人兽共患寄生虫病重点实验室,陕西 延安 716000延安大学医学院基础医学院,陕西 延安 716000||延安市动物及人兽共患寄生虫病重点实验室,陕西 延安 716000
医药卫生
miR-141恶性肿瘤作用机制临床价值治疗靶点
miR-141malignant tumorsmechanism of actionclinical valuetherapeutic target
《解放军医学杂志》 2026 (4)
512-521,10
This work was supported by the National Natural Science Foundation of China(32360891,82360554,81860444),the Special Scientific Research Program for Serving Local Development of Shaanxi Provincial Department of Education(24JC087),the Science and Technology Plan Project of Yan'an City(2024-NYGG-125),the Independent Research Project of Shaanxi Key Laboratory of Chinese Jujube(sxhzdsys-zj23-01),the Yan'an Education,Science and Culture Development Foundation(YAU202510700),and the Doctoral Research Startup Project of Yan'an University(YDBK2022-18) 国家自然科学基金(32360891,82360554,81860444)陕西省教育厅服务地方专项科学研究计划项目(24JC087)延安市科技计划项目(2024-NYGG-125)陕西省红枣重点实验室自主研究课题(sxhzdsys-zj23-01)延安教科文发展基金(YAU202510700)延安大学博士科研启动项目(YDBK2022-18)
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