加味葛根芩连汤治疗晚期大肠癌临床研究OA

Objective To observe the clinical efficacy of modified Gegen Qinlian Decoction in the treatment of advanced colorectal cancer.Methods A total of 118 patients with advanced colorectal cancer admitted to the Department of Oncology of Integrated Traditional Chinese and Western Medicine,Tangshan People's Hospital,from December 2022 to December 2023 were selected and randomly divided into two groups using a random number table method.The control group included 59 patients and received conventional XELOX chemotherapy.The treatment group included 59 patients and received modified Gegen Qinlian De-coction in addition to the treatment given to the control group.Intestinal microbiota levels,serum tumor-related factor levels,T-lymphocyte proportions,and inflammatory factor levels were compared between the two groups before and after treatment.Clinical efficacy and adverse reactions were also recorded and compared.Results After treatment,both groups showed increased levels of Bifidobacterium and Lactobacillus compared with their pre-treatment levels(P<0.05),while Enterococcus and Enterobacter levels decreased compared with their pre-treatment levels(P<0.05).After treatment,the treatment group had higher levels of Bifidobacterium and Lactobacillus than the control group(P<0.05),and lower levels of Enterococcus and Enterobacter than the control group(P<0.05).After treatment,the levels of vascular endothelial growth factor,matrix metalloproteinase-2,matrix metalloproteinase-7,matrix metalloproteinase-9,hypersensitive C-reactive protein,tumor necrosis factor-α,and interleukin-6 decreased in both groups(P<0.05),with all levels being lower in the treatment group than in the control group(P<0.05).After treatment,CD8+levels increased in both groups compared with pre-treatment levels(P<0.05),whereas CD4+and CD4+/CD8+ratios decreased in both groups compared with pre-treatment levels(P<0.05).However,after treatment,the treatment group had higher CD4+and CD4+/CD8+ratios than the control group(P<0.05),and lower CD8+levels than the control group(P<0.05).The total effective rate was 98.31%(58/59)in the treatment group and 86.44%(51/59)in the control group,with the treatment group showing a significantly higher total effective rate than the control group(P<0.05).The overall incidence of adverse reactions was 1.69%(1/59)in the treatment group and 15.25%(9/59)in the control group,with the treatment group showing a lower incidence than the control group(P<0.05).Conclusion Modified Gegen Qinlian Decoction shows a significant clinical effect in the treatment of advanced colorectal cancer.It can im-prove intestinal microbiota,alleviate systemic inflammatory responses,reduce serum tumor-related factor levels,enhance immu-nity,and has good safety.