运动习惯与帕金森病轻度认知障碍的关联路径分析OA

Objective:To construct a structural equation model and analyze the impact pathways of exercise habits on mild cognitive impairment in Parkinson disease(PD-MCI).Methods:A cross-sectional study was conducted,involving 151 PD patients who visited the Parkinson's Disease Clinic at the Chinese PLA General Hospital in Beijing from October 2021 to June 2023.Patients were surveyed using a general information questionnaire,the Montreal Cognitive Assessment(MoCA),Part Ⅲ of the Unified Parkinson's Disease Rating Scale(UPDRS-Ⅲ),the Parkinson's Disease Sleep Scale-2(PDSS-2),and the Hamilton Depression Scale(HAMD).Mplus 8.3 software was used for association pathway analysis.Results:Both direct and indirect association pathways between exercise habits and the diagnostic risk of PD-MCI were significant(P＜0.05).These pathways included:exercise habits→PD-MCI(—0.153[—0.305,—0.006]),exercise habits→motor sym-ptoms→PD-MCI(—0.070[—0.129,—0.029]),exercise habits→motor symptoms→depressive symptoms→PD-MCI(—0.025[—0.051,—0.011]),exercise habits→motor symptoms→sleep quality → PD-MCI(—0.011[—0.028,—0.003]),and exercise habits→depressive symptoms→PD-MCI(—0.030[—0.067,—0.005]).Con-clusion:Exercise habits can directly predict the diagnostic risk of PD-MCI.They can also indirectly predict the diagnostic risk of PD-MCI through the mediating effects of motor symptoms and depressive symptoms,as well as through the chained mediating effects of motor symptoms combined with depressive symptoms or sleep quality.