超声造影时间-强度曲线参量成像辅助鉴别乳腺局灶性病变良恶性的价值OA

Objective To investigate the value of contrast-enhanced ultrasound(CEUS)time-intensity curve(TIC)parametric imaging in assisting physicians with different levels of experience in improving the diagnostic performance for breast focal lesions.Methods Clinical and imaging data of 98 female patients with breast tumors who underwent ultrasound examination and had pathological confirmation by biopsy or surgery were retrospectively collected.Forty-nine benign lesions and 49 malignant lesions confirmed by pathology were included as the benign group and malignant group,respectively.Two junior physicians and two senior physicians independently analyzed the CEUS and TIC parametric images of all cases using two protocols to determine whether the lesions were benign or malignant.Protocol A included conventional two-dimensional ultrasound and CEUS images,whereas Protocol B included conventional two-dimensional ultrasound,CEUS images,and TIC parametric images.Fisher's exact test was used to compare differences in TIC parametric image classifications.Kappa analysis was performed to assess the diagnostic consistency of junior and senior physicians using different imaging methods.Receiver operating characteristic(ROC)curve analysis was used to evaluate the diagnostic performance of different imaging methods for breast focal lesions by physicians with different levels of experience,and the area under the curve(AUC)was calculated.Differences in AUC values were compared using the DeLong test.Results TIC parametric image classification results evaluated by physicians with different levels of experience showed that benign lesions were mainly classified as completely dispersed type and predominantly dispersed type,whereas malignant lesions were mainly classified as completely concentrated type and predominantly concentrated type.Consistency analysis showed that the diagnostic consistency of both junior and senior physicians was significantly improved after using Protocol B(all P<0.05).DeLong test results showed that Protocol B improved the diagnostic performance of both junior and senior physicians(all P<0.05).The diagnostic performance of junior physicians using Protocol B was similar to that of senior physicians using Protocol A(P>0.05).Conclusion CEUS combined with TIC parametric imaging can assist physicians with different levels of experience in improving the differential diagnostic ability for breast focal lesions and may provide a reference for clinical decision-making.