老年慢性心力衰竭患者左心室重构与脂联素、胎盘生长因子、内脏脂肪组织来源的丝氨酸蛋白酶抑制剂的关系OA

Objective To analyze the relationship between left ventricular remodeling(LVR)and adiponectin(APN),placental growth factor(PLGF),and visceral adipose tissue-serine protease inhibitor(Vaspin)in elderly patients with chronic heart failure(CHF).Methods This study was a retrospective analysis,a total of 60 elderly patients with CHF combined with LVR admit-ted to the Second Affiliated Hospital of Xi'an Medical College from 2022 to 2024 were collected as the LVR group.Additionally,anoth-er 60 elderly patients without LVR admitted to our hospital during the same period were collected as the simple CHF group.LVR related parameters[left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),left ventricular posterior wall thickness(LVPWT),interventricular septum thickness(IVST)],serum APN,PLGF,and vaspin levels were compared between the two groups;the relationship between serum APN,PLGF,and vaspin and LVR in elderly CHF patients was analyzed.Results The LVEF value in the LVR group was lower than that in the simple CHF group(P<0.05),and the LVEDD,LVPWT,and IVST values were higher than those in the simple CHF group(P<0.05).The levels of Vaspin and APN in the LVR group were lower than those in the simple CHF group(P<0.05),and the serum PLGF was higher than that in the simple CHF group(P<0.05).According to the Pearson correlation test,serum PLGF was negatively correlated with LVEF and positively correlated with LVEDD,LVPWT,and IVST(P<0.05).Serum APN and Vaspin were positively correlated with LVEF and negatively correlated with LVEDD,LVPWT,and IVST(P<0.05).Results of multivariate logistic regression analysis showed that serum PLGF overexpression was a risk factor for LVR in elderly CHF patients,while APN and Vaspin were protective factors(P<0.05).Results of ROC curves analysis showed that the area under the curve of serum APN,PLGF,and Vaspin alone and in combination for evaluating LVR in elderly CHF patients were all grea-ter than 0.71,which had certain evaluation value,and the area under the curve value could be increased by combined detection.Con-clusion LVR is associated with serum APN,PLGF and vaspin levels in elderly patients with CHF,and the combined detection of APN,PLGF and vaspin can improve the evaluation value of LVR in elderly patients with CHF.