干细胞与类器官技术在烧伤创面修复中的研究进展与应用OA

Burn injuries often lead to persistent physiological and psychological sequelae.The management of extensive full-thickness burns and chronic non-healing wounds remains a considerable clinical challenge,as conventional therapies frequently fail to achieve simultaneous restoration of skin architecture and biological function.Regenerative medicine has emerged as a transformative approach,with stem cells and skin organoids demonstrating exceptional promise in facilitating wound closure,promoting true skin regeneration,and reconstructing appendages.This review comprehensively examines current research and clinical applications,citing key studies(e.g.,growth arrest-specific gene 6-overexpressing bone marrow mesenchymal stem cells accelerating wound healing,induced pluripotent stem cell-derived hair-bearing organoids)for illustration.Evidence indicates that stem cells enhance wound healing through multiple processes,including angiogenesis promotion,inflammation modulation,stimulation of cellular proliferation and migration,and attenuation of scar formation.Skin organoids,which recapitulate the multilayered organization and functionality of native skin,provide valuable platforms for in vitro modeling and transplantation-based repair.The review also critically assesses barriers to clinical translation,such as tumorigenicity,immunogenicity,challenges in scale-up production and standardization,and relevant ethical and regulatory hurdles.Combined stem cell-organoid approaches,integrated with innovative smart biomaterials and three-dimensional bioprinting technologies,are poised to enable precision medicine and personalized rehabilitation strategies for burn patients,ultimately achieving fully functional skin regeneration.