宫颈癌近距离放射治疗剂量学与临床疗效研究OA

Cervical cancer is one of the most common malignancies among women worldwide,ranking fourth in both incidence and mortality,and it poses a significant threat to women's health globally.Brachytherapy plays a pivotal role in the comprehensive management of locally advanced cervical cancer(LACC),and the choice of applicator technique directly influences dose distribution to the target volume as well as radiation exposure to organs at risk(OARs).This article systematically reviews recent advances in brachytherapy techniques for LACC,including intracavitary brachytherapy(ICBT),interstitial brachytherapy(ISBT),and combined intracavitary/interstitial brachytherapy(IC/ISBT).The clinical applications and dosimetric characteristics of these approaches are summarized.By synthesizing evidence from multiple clinical studies,differences among these techniques in terms of target coverage,OAR dose sparing,and clinical outcomes are comparatively analyzed.Current evidences indicates that IC/ISBT demonstrates certain advantages over ICBT or ISBT alone in improving target dose coverage and reducing radiation exposure to OARs,particularly in patients with large or irregularly shaped tumors.However,as an invasive procedure,IC/ISBT is associated with potential complications,and its indications should be carefully evaluated based on tumor characteristics and individual patient conditions.In summary,there is currently no unified standard for the selection of brachytherapy techniques and applicators in the treatment of LACC.Future prospective studies and further dosimetric optimization strategies are warranted to clarify the role of different techniques in individualized treatment and to provide higher-quality evidence for clinical decision-making.