基于纳米标签的侧流免疫分析在滥用药物即时检测中的研究进展OA

The abuse of drugs,including narcotics and psychotropic substances,antibiotics,and additives,has become a significant threat to global public health security and social stability.Therefore,the development of rapid,efficient,portable,and on-site screening technologies suitable for resource-limited environments is of great importance for the early detection,effective regulation,and monitoring of trends in drug abuse.Lateral flow immunoassay(LFIA),leveraging its operational simplicity,rapid response,cost-effectiveness,and suitability for non-laboratory settings,has emerged as a pivotal platform for point-of-care testing(POCT)of abuse drugs.Among these,nanotags,serving as signal carriers,play a key role in enabling high-performance LFIA by conjugating antibodies to output detection signals.This review began with a brief introduction to LFIA technology,systematically summarized recent research progress in LFIA recognition mechanisms,novel nanolabels,and signal transduction strategies for drug abuse detection,and discussed the remaining challenges and future trends in this field.