皮肤间质液微针诊疗一体化研究进展OA

The development of integrated diagnosis and treatment signifies a revolutionary advancement in modern medicine.Interstitial fluid(ISF),serving as a biomarker-rich"subcutaneous laboratory",offers novel avenues for research and application in minimally invasive disease monitoring and therapy.Micro-needle technology,with its minimally invasive nature and excellent system integration capabilities,provides an ideal technical platform for ISF sampling,biomarker detection,and intelligent drug delivery.This paper systematically reviews the applications and progresses of microneedle-based integrated diagnostic and therapeutic systems in ISF detection.It outlines the structural characteristics and fundamental functions of various microneedle types,focuses on electrochemical and optical sensing strategies employed in microneedle sensors,subsequently elaborates on microneedle drug delivery systems constructed based on endogenous response and exogenous trigger mechanisms.Finally,specific application cases of this technology across various diseases are reviewed.Although challenges remain in detection specificity and drug loading capacity,driven by material innovation,intelligent algorithms,and advanced manufacturing processes,microneedle-based integrated diagnostic and therapeutic systems are rapidly advancing towards personalized and precision medicine.