基于纳米材料的心肌肌钙蛋白Ⅰ分析方法研究进展OA
Recent Progress in Nanomaterials-based Analytical Methods for Detection of Cardiac Troponin Ⅰ
心肌肌钙蛋白I(Cardiac troponin I,cTnI)对心肌损伤具有高度的特异性和敏感性,是急性心肌梗死(Acute myocardial infarction,AMI)等高风险心血管疾病(Cardiovascular disease,CVD)早期诊断的重要生物标志物.近年来,为了满足高风险CVD早期筛查的需求,研究者开发了大量基于纳米材料的高性能分析方法用于血液样本中低丰度cTnI的精准检测.本文对近五年该领域的相关研究进展进行了概述,重点讨论了不同纳米材料的理化特性对cTnI电化学和光学检测方法性能的提升效果,分析了其在实际临床中的应用现状和未来的发展趋势,以期为研发高风险CVD早期精准筛查新方法提供参考.
Cardiac troponin I(cTnI)exhibits high specificity and sensitivity for myocardial injury,serving as a crucial biomarker for the early diagnosis of high-risk cardiovascular diseases(CVD),such as acute myocardial infarction(AMI).Recently,to meet the demand for early screening of high-risk CVD,various nanomaterial-based analytical methods with high-performance have been developed for the precise detection of low-abundance cTnI in blood samples.This review summarized recent research advancements over the past five years,focusing on the physicochemical properties of different nanomaterials to enhance the performance of electrochemical and optical detection methods for cTnI.It also discussed the limitations and prospects of as-developed methods in clinical applications,providing a detailed outline for the development of new methods for precise early screening of high-risk CVD.
李铸衡;王令萱;吴复超;宋丹;王皓冬;王振新
吉林省教育学院,长春 130022中国科学院长春应用化学研究所,电分析化学重点实验室,长春 130022中国科学院长春应用化学研究所,电分析化学重点实验室,长春 130022中国科学院长春应用化学研究所,电分析化学重点实验室,长春 130022吉林大学白求恩第一临床医院心内科,长春 130021中国科学院长春应用化学研究所,电分析化学重点实验室,长春 130022
心肌肌钙蛋白I生物传感器心血管疾病即时检验评述
Cardiac troponin IBiosensorsCardiovascular diseasePoint-of-care testingReview
《分析化学》 2026 (4)
554-567,中插1-中插6,20
吉林省自然科学基金-国家重点实验室(学科类)重大专项(No.SKL202302030)资助. Supported by the Natural Science Foundation of Jilin Province-Key Special Project of National Key Laboratory(No.SKL202302030).
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