基于彩色Petri网的针刺治疗常年性变应性鼻炎的动态仿真模型分析OA

OBJECTIVE Based on the traditional Chinese medicine theory of"lung-spleen-kidney involvement with simultaneous regulation of the triple energizer",this study constructed a colored Petri nets(CPNs)dynamic simulation model to quantitatively analyze acupuncture treatment for perennial allergic rhinitis(PAR).METHODS An integrated"acupuncture-meridian-zang-fu"CPNs framework was developed,in which zang-fu functional states were represented as continuous quantitative variables.Three intervention pathways,namely comprehensive acupoint selection,local acupoint selection,and an untreated control group,were designed and compared in terms of recovery rate,steady-state level,and overall system synergy.RESULTS All three groups exhibited a recovery trend from a deficient state to a balanced state.The comprehensive acupoint selection group showed overall advantages in improving the functions of the core zang organs and maintaining steady states,whereas the local acupoint selection group demonstrated greater advantages in overall system synergy.Both outperformed the untreated control group.CONCLUSION The CPNs model can characterize the dynamic process of acupuncture intervention for PAR,establish an interpretable mapping between traditional Chinese medicine syndrome differentiation semantics and system dynamic states,and provide a quantitative modeling framework for digital acupuncture research.