隔日温差与银屑病门诊就诊量的负向关联及人群异质性:一项时间序列分析与健康教育启示OA

Objective Evidence regarding the independent health effects of short-term,acute temperature fluctuations on psoriasis remains scarce.This study aimed to investigate the association pattern,Lagged effects,and population heterogeneity between the temperature change between neighboring days(TCN)and outpatient visits for psoriasis,providing a reference for identifying environmental risk factors for psoriasis.Methods This was a retrospective time-series study.Data on psoriasis outpatient visits were collected from 2 general hospitals in Chongqing between December 1,2013 and December 31,2019,encompassing 24 324 patient visits.Concurrent meteorological and air pollutant data were obtained from the local meteorological bureau and the China National Environmental Monitoring Centre.The primary exposure was TCN,with stratification by sex(male/female)and age(<40 years/≥40 years).A distributed Lag nonlinear model(DLNM)was used to analyze the association between TCN and daily outpatient visits.Using the interquartile range(IQR)of TCN as the unit of change and the 25th percentile as the reference,the relative risk(RR)and its 95%confidence interval(CI)were calculated.Models were adjusted for long-term trends,meteorological factors(wind speed,rainfall,relative humidity),PM2.5,day of the week,and public holidays.Differences in effects between subgroups were tested using the Z-test.Results In the total population,TCN was negatively associated with psoriasis outpatient visits.For each 2.1℃increase in TCN(one IQR),significant single-day Lagged effects were observed at Lag1 and Lag2,with an RR of 0.997(95%CI:0.995 to 0.999,P<0.001)at Lag2;cumulative effects were significant from Lag01 to Lag07,with an RR of 0.986(95%CI:0.983 to 0.989,P<0.001)at Lag07.Stratified analyses showed significant effects in males and those aged≥40 years at single-day Lags Lag0 and Lag1 and cumulative Lags from Lag00 to Lag07,with an RR of 0.983(95%CI:0.979 to 0.986,P<0.001)at Lag07 for males and an RR of 0.981(95%CI:0.977 to 0.985,P<0.001)at Lag07 for those aged≥40 years.Effects were weaker in females and those aged<40 years,with statistical significance observed only for certain Lag days.Heterogeneity tests indicated significant differences between sexes at Lag0,Lag00,and Lag07,and between age groups at Lag7 and Lag07,suggesting that reductions in healthcare-seeking behavior associated with higher TCN were more pronounced in male patients and those aged≥40 years.Conclusion Higher TCN is statistically associated with a reduction in psoriasis outpatient visits.Sex and age showed suggestive modifying effects,with stronger associations observed in males and individuals aged≥40 years,although the magnitude of the effect differences was very small.Countermeasures In the future,monitoring acute temperature fluctuations could be integrated into community-based health management systems for chronic skin diseases.Using meteorological warnings,an environmental exposure risk communication mechanism stratified by population and sex can be established to deliver precise recommendations regarding optimal times for outdoor activities to psoriasis patients,thereby optimizing behavioral intervention strategies and guiding patients'decisions on seeking medical care.