化痰平喘合剂治疗慢性阻塞性肺疾病急性加重期痰热壅肺证38例OA

Objective:To investigate the clinical effect of Huatan Pingchuan mixture in the treatment of acute exac-erbation of chronic obstructive pulmonary disease(AECOPD)with phlegm-heat obstructing the lung.Methods:A total of 80 AECOPD patients with phlegm-heat obstructing the lung were randomly divided into treatment group and control group.The patients in the control group received conventional Western medicine treatment,and those in the treatment group re-ceived Huatan Pingchuan mixture in addition to the treatment in the control group.Each course of treatment was 7 days,and both groups were treated for 2 courses.The two groups were observed in terms of the time to relief of cough and expectoration,duration of antibiotic use,COPD assessment test(CAT)score,traditional Chinese medicine(TCM)syndrome score,arterial blood gas parameters,and safety indicators,and clinical outcome was assessed.Results:There was a significant dif-ference in overall response rate between the treatment group and the control group[92.11％(35/38)vs 79.49％(31/39),P＜0.05].Compared with the control group,the treatment group had significantly better results of time to relief of cough and expectoration and duration of antibiotic use(P＜0.05).After treatment,both groups had significant changes in CAT score,TCM syndrome score,and arterial blood gas parameters,and there were significant differences in these indicators between the two groups after treatment(P＜0.05).There was no significant difference in the incidence rate of adverse re-actions between the treatment group and the control group[5.26％(2/38)vs 7.69％(3/39),P＞0.05].Conclusion:In the treatment of AECOPD with phlegm-heat obstructing the lung,Huatan Pingchuan mixture can significantly improve clinical symptoms,pulmonary ventilation function,and anoxia and shorten the time to relief of cough and expectoration and the duration of antibiotic use,with a marked clinical effect and a favorable safety profile.