帕金森病合并肌少症共病的研究进展OA

The comorbidity of Parkinson's disease(PD)and sarcopenia in the elderly has garnered increasing research interest in recent years.This condition can accelerate the decline of motor function and elevate the risk of falls.The underlying pathogenesis is multifactorial,involving processes such as neuroinflammation,oxidative stress,hormonal and metabolic dysregulation,mitochondrial dysfunction,neuromuscular junction impairment,gut microbiota dysbiosis,exosome-mediated propagation of α-synuclein pathology,non-motor symptoms,pharmacological effects,and neurodegeneration.Intervention strategies emphasize a multi-targeted,integrated management approach,including personalized resistance training,nutritional support,and innovative therapies targeting the gut microbiome.Despite accumulating evidence,considerable controversies remain regarding the pathogenic mechanisms,diagnostic criteria,and optimal interventions for this comorbidity.This review summarizes recent advances in the study of PD complicated by sarcopenia,aiming to inform strategies for improving functional outcomes and quality of life in affected patients.