富含甘油三酯脂蛋白及其残粒在阿尔茨海默病合并心血管风险中的作用与防治OA

Dysregulated metabolism of triglyceride-rich lipoproteins(TRLs)and remnants constitutes a shared risk factor for both cardiovascular disease(CVD)and Alzheimer's disease(AD),with close pathological interconnections between the two conditions.This review synthesizes current evidence on the common mechanisms through which TRLs and their remnants contribute to both CVD and AD,primarily involving the promotion of atherosclerosis,induction of systemic and neuroinflammation,and exacerbation of insulin resistance.By integrating clinical and genetic findings,it highlights the potential bridging role of TRLs between cardiovascular risk and cognitive decline.Furthermore,the review summarizes advances and limitations of current management strategies including lifestyle interventions,conventional pharmacotherapy,and emerging treatments within the framework of cardiocerebral comorbidity.It proposes a patient-centered,multidisciplinary integrated care pathway aimed at optimizing the management of these co-occurring conditions.Future research should focus on novel targets within TRLs metabolism to develop more effective interventions and improve outcomes in this high-risk population.