轻度认知障碍患者心肺体适能的改变及其与认知功能的相关性研究OA

Objective:To investigate changes in cardiorespiratory fitness in patients with mild cognitive impairment(MCI)and their correlation with cognitive dysfunction.Methods:A total of 770 elderly patients hospitalized long-term at Zhongren Geriatric Care Hospital in Jinshan District,Shanghai,were screened from March 2024 to March 2025.Ultimately,91 individuals completed both neuropsychological assessments and cardiorespiratory fitness evaluations.Based on scores from the Montreal Cognitive Assessment-Basic(Moca-B),participants were divided into an MCI group(score 14～20,n=60)and a healthy control group(score 20～30,n=31).Global cognitive function was assessed using the Moca-B;cognitive subdomains were evaluated using the Digit Span Test,Trail Making Test,and Wechsler Digit Symbol Substitution Test.Cardiorespiratory fitness was assessed via grip strength(left and right hand),Timed Up and Go test,and limits of stability.Partial correlation analysis was used to explore the relationship between cardiorespiratory fitness and cognitive function in MCI patients.Results:Compared with the healthy control group,the MCI group showed statistically significant differences in years of education,Moca-B score,Trail Making Test-A,Symbol Digit Modalities Test,backward digit span,verbal fluency test,activities of daily living(ADL),grip strength(both hands),limits of stability,and TUG performance(P<0.05).Partial correlation analysis revealed a significant positive correlation between grip strength and cognitive function in MCI patients(P<0.001).Further analysis indicated that grip strength and limits of stability were independent risk factors affecting cognitive function in older adults.Conclusions:Patients with MCI exhibit measurable changes in cardiorespiratory fitness,among which grip strength is closely associated with cognitive function.Both grip strength and limits of stability may serve as early indicators of cognitive decline in older adults.