精准医学重塑阿尔茨海默病防诊治新范式OA
Precision medicine is transforming the prevention,diagnosis,and treatment of Alzheimer's disease
阿尔茨海默病(AD)是全球性的重大健康挑战.近年来,随着大数据与前沿技术驱动的精准医学发展,AD研究与实践正经历一场深刻的范式变革,其核心是从基于临床症状、被动应对的"一刀切"模式,转向一个以生物学证据为基础、以早期疾病修饰干预为目标的精准医学体系.本文系统梳理并探讨了精准医学背景下的AD早期预防、诊断和治疗的新方式,旨在为该疾病的诊治提供新视角与可行路径.
Alzheimer's disease(AD)represents a major global health challenge.In recent years,driven by big data and cutting-edge technologies,precision medicine has been guiding AD research and practice through a profound transformation.The core of this shift moves away from a reactive,symptom-based,"one-size-fits-all"model towards a new paradigm of precise diagnosis and treatment grounded in biological evidence and aimed at early disease modification.This review systematically explores the latest advances in early prevention,diagnosis,and treatment of AD within this framework,aiming to provide new perspectives and feasible pathways towards ultimately conquering the disease.
黄钰媛;郁金泰
复旦大学附属华山医院,国家神经疾病医学中心,上海 200040复旦大学附属华山医院,国家神经疾病医学中心,上海 200040
医药卫生
阿尔茨海默病早期诊断预防生物标志物
Alzheimer's diseaseEarly diagnosisPreventionBiomarkers
《阿尔茨海默病及相关病》 2026 (3)
147-149,172,4
科技创新2030-"脑科学与类脑研究"重大项目(2022ZD0211600),国家自然科学基金(82401647),复旦大学"青年临床专职科研队伍"人才培育项目(DGF828024-3/018),上海市卫生健康委员会科研项目(20234Y0307).
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