抗炎1号方治疗慢性肝病重叠巨细胞病毒感染导致胆汁淤积的疗效观察OA

Objective:Elucidate the efficacy and action mechanism of anti-inflammatory formula No.1 in the treatment of chronic liver disease with cytomegalovirus infection.Methods:A retrospective analysis was conducted on 30 cases of chronic liver diseases complicated with cytomegalovirus infection who were treated with Anti-inflammatory Prescription No.1 combined with western medicine,and 30 cases who were treated with western medicine alone.The clinical efficacy and characteristics of bile acid metabolomics of the two groups were compared.Results:The clinical symptoms and signs of patients with liver function impairment caused by chronic liver diseases complicated with cytomegalovirus infection in both groups were relatively mild.When comparing the biochemical indexes before and after treatment,there was no difference in total bilirubin(TBil)before treatment between the treatment group(285.52±125.34)μmol/L)and the control group(338.28±129.19)μmol/L)(P＞0.05).Two weeks and four weeks after treatment,the TBil level in the treatment group decreased significantly compared with that in the control group(P＜0.01).There was no significant difference in alanine aminotransferase(ALT)before treatment between the treatment group(681.08±587.07)U/L)and the control group(670.50±924.61)U/L)(P＞0.05).Two weeks and four weeks after treatment,the ALT level in the treatment group decreased compared with that in the control group(P＜0.05).There was no difference in total bile acid(TBA)between the two groups before treatment.Two weeks and four weeks after treatment,the TBA level in the treatment group decreased significantly compared with that in the control group(P＜0.01).There was no statistical difference in the levels of tumor necrosis factor(TNF-α)and interleukin-6(IL-6)between the two groups before treatment.After treatment,the levels of TNF-α and IL-6 in the treatment group decreased significantly compared with those in the control group(P＜0.01).Bile acid metabolomics analysis detected 29 substances,all of which decreased after treatment compared with that before treatment,and cholic acid(CA)and chenodeoxycholic acid(CDCA)showed statistical significance(P＜0.05).The total effective rate of the treatment group was significantly higher than that of the control group(x2=8.523,P=0.004),and no adverse reactions occurred in both groups during the treatment process.Conclusion:The treatment group for chronic liver diseases complicated with cytomegalovirus infection is better in improving the clinical biochemical indexes of patients,reducing the levels of TNF-α and IL-6,and improving bile acid metabolism.It is suggested that the mechanism of Anti-inflammatory Prescription No.1 in treating cholestasis caused by chronic liver diseases complicated with cytomegalovirus infection may be to down-regulate the expression of TNF-α and IL-6,improve the composition of bile acids,reduce the production of CA and CDCA,and change the composition of bile acids at the same time,so as to reduce the oxidative stress and inflammatory response of the liver,inhibit the synthesis of bile acids,increase bile secretion,improve liver injury,and promote the repair of liver cells.