表皮蛋白介导害虫抗药性机制的研究进展OA

The evolution of insecticide resistance in pests has become a critical challenge restricting the sustainable development of global agriculture.Compared with target-site resistance and metabolic resis-tance,cuticular penetration resistance is an early-stage resistance strategy adopted by insects to defend against insecticides with contact action.It primarily reduces the efficiency of insecticide penetration through the insect's outer barrier and its delivery to the target site.On one hand,it decreases the amount of insecticide that penetrates;on the other hand,it prolongs the detoxification time of the insec-ticide within the body,thereby enhancing the resistance effect.This mechanism often synergizes with other resistance mechanisms.This systematic review summarizes the latest research progress on the cuticle-mediated mechanisms of insecticide resistance in pests.It focuses on the molecular basis under-lying the formation of cuticular penetration resistance,the key regulatory networks,and its evolutionary characteristics.Future perspectives are also discussed,aiming to provide new insights for pest resistance management strategies.