骨松益骨方加减对肾虚血瘀型绝经后骨质疏松症患者骨代谢与脂代谢的影响OA

Objective:To observe the effects of modified Gusong Yigu formula on bone metabolism and lipid metabo-lism in postmenopausal osteoporosis patients with kidney deficiency and blood stasis,and further explore the correla-tion between bone metabolism and lipid metabolism.Methods:Seventy patients with postmenopausal osteoporosis of kid-ney deficiency and blood stasis pattern,treated from January 2024 to May 2025 were selected.The 70 patients were ran-domly divided into the observation group and the control group using the random number table method,with 38 cases in the observation group and 32 cases in the control group.The control group was treated with calcium carbonate D3 tablets,calcitriol soft capsules,and risedronic acid sodium tablets.On the basis of the control group,the observation group was treated with Gusong Yigu formula.The treatment lasted for 3 months.Before and after the treatment,the changes in bone metabolism indicators,such as β-C-terminal telopeptide of type Ⅰ collagen(β-CTX),N-terminal propeptide of type Ⅰprocollagen(N-MID),and total Ⅰ-type collagen amino-terminal propeptide(PINP),and lipid metabolism indicators,such as triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C),as well as atherosclerosis index[AI=(TC-HDL)/HDL]were observed.At the same time,the correlation between bone metabolism markers and lipid metabolism indicators was analyzed.Results:After 3 months of treatment,both groups showed significant improvements in the β-CTX,N-MID,and PINP compared to before treatment(P<0.05);there was no statistical significance in the improvement of TG,TC,HDL-C,LDL-C,and AI between the two groups before and after treatment(P>0.05);after 3 months of treatment,the lipid metabolism indicators in the observa-tion group showed statistically significant improvements compared to baseline(P<0.05).When comparing the two groups,the levels of N-MID and PINP in the observation group were higher than those in the control group after 3 months of treatment(P<0.05),while the level of β-CTX was lower than that in the control group(P<0.05);the observation group showed better improvement in lipid metabolism indicators(including TG,TC,and LDL-C)compared with the con-trol group(P<0.05),and also showed better improvement in the AI(P<0.05).Correlation analysis of bone metabolism indicators and lipid metabolism indicators:serum osteocalcin,PINP were negatively correlated with TG,TC,LDL-C,and AI(P<0.05),and positively correlated with HDL-C(P<0.05).β-CTX was positively correlated with TG,TC,LDL-C,and AI(P<0.05),but showed no correlation with HDL-C(P>0.05).Conclusion:The modified Gusong Yigu formula can improve the bone metabolism-related indicators in postmenopausal osteoporosis patients with kidney deficiency and blood stasis syndrome;at the same time,it can regulate the lipid metabolism of patients,reduce TC,TG and LDL-C levels,and increase HDL-C levels.Moreover,there is a significant correlation between bone metabolism and lipid metabolism.Im-proving lipid metabolism may therefore promote the improvement in bone metabolism.